Kat6b Modulates Oct4 and Nanog Binding to Chromatin in Embryonic Stem Cells and Is Required for Efficient Neural Differentiation

Chromatin remodeling is fundamental for the dynamical changes in transcriptional programs that occur during development and stem cell differentiation. The histone acetyltransferase Kat6b is relevant for neurogenesis in mouse embryos, and mutations of this gene cause intellectual disability in humans...

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Guardado en:
Detalles Bibliográficos
Publicado: 2019
Materias:
CRISPR/Cas9
fluorescence correlation spectroscopy
neural progenitors
pluripotency transcription factors
super-enhancer
CRISPR associated endonuclease Cas9
heterochromatin protein 1
heterochromatin protein 1 alpha
histone acetyltransferase
histone acetyltransferase Kat6b
Ki 67 antigen
messenger RNA
octamer transcription factor 4
short hairpin RNA
transcription factor NANOG
transcription factor Sox2
unclassified drug
animal cell
animal experiment
Article
cell fate
cell lineage
cell proliferation
cell structure
cell viability
cellular distribution
chromatin
chromatin assembly and disassembly
controlled study
CRISPR-CAS9 system
embryo
embryonic stem cell
epigenetics
gene expression
gene knockout
genetic transcription
immunochemistry
Kat6b gene
male
molecular dynamics
mouse
nerve cell differentiation
nerve cell plasticity
neural stem cell
neuromodulation
nonhuman
priority journal
protein analysis
protein binding
protein expression
protein function
protein protein interaction
RNA sequence
stem cell self-renewal
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00222836_v431_n6_p1148_Cosentino
http://hdl.handle.net/20.500.12110/paper_00222836_v431_n6_p1148_Cosentino
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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