Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of trypanosoma cruzi farnesyl diphosphate synthase

Linear 2-alkylaminoethyl-1,1-bisphosphonates are effective agents against proliferation of Trypanosoma cruzi, the etiologic agent of American trypanosomiasis (Chagas disease), exhibiting IC 50 values in the nanomolar range against the parasites. This activity is associated with inhibition at the low...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Szajnman, Sergio Hernán, Rodríguez, Juan Bautista, Amzel, León Mario
Publicado:	2012
Materias:	alkyl group allyl compound amine antitrypanosomal agent bisphosphonic acid derivative geranyltransferase geranyltransferase inhibitor isoprenoid methyl group unclassified drug article binding affinity Chagas disease chemical bond complex formation conformation crystal structure drug design drug protein binding drug synthesis enthalpy entropy enzyme active site enzyme inhibition hydrophobicity IC 50 isothermal titration calorimetry nonhuman structure activity relation thermodynamics Trypanosoma cruzi X ray crystallography Calorimetry Crystallography, X-Ray Drug Design Enzyme Inhibitors Geranyltranstransferase Magnesium Models, Molecular Phosphonic Acids Protein Conformation Thermodynamics
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00222623_v55_n14_p6445_Aripirala http://hdl.handle.net/20.500.12110/paper_00222623_v55_n14_p6445_Aripirala
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of trypanosoma cruzi farnesyl diphosphate synthase
por: Aripirala, S., et al.

Approaches for Designing new Potent Inhibitors of Farnesyl Pyrophosphate Synthase
por: Rodríguez, Juan Bautista, et al.
Publicado: (2016)

Approaches for Designing new Potent Inhibitors of Farnesyl Pyrophosphate Synthase
por: Rodriguez, J.B., et al.

2-alkylaminoethyl-1,1-bisphosphonic acids are potent inhibitors of the enzymatic activity of Trypanosoma cruzi squalene synthase
por: Szajnman, Sergio Hernán, et al.
Publicado: (2012)

2-alkylaminoethyl-1,1-bisphosphonic acids are potent inhibitors of the enzymatic activity of Trypanosoma cruzi squalene synthase
por: Rodrígues-Poveda, C.A., et al.
Publicado: (2012)

2-alkylaminoethyl-1,1-bisphosphonic acids are potent inhibitors of the enzymatic activity of Trypanosoma cruzi squalene synthase
por: Rodrígues-Poveda, C.A., et al.

2-alkylaminoethyl-1,1-bisphosphonic acids are potent inhibitors of the enzymatic activity of Trypanosoma cruzi squalene synthase
por: Rodrígues-Poveda, C.A., et al.
Publicado: (2012)

Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase
por: Szajnman, Sergio Hernán, et al.
Publicado: (2005)

Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase
por: Szajnman, S.H., et al.

Evaluation of enzyme inhibitors in drug discovery a guide for medicinal chemists and pharmacologists /
por: Copeland, Robert Allen
Publicado: (2013)

Studies of 4-arylthiazolylhydrazones derived from 1-indanones as Trypanosoma cruzi squalene epoxidase inhibitors by molecular simulations
Publicado: (2018)

Studies of 4-arylthiazolylhydrazones derived from 1-indanones as Trypanosoma cruzi squalene epoxidase inhibitors by molecular simulations
por: Noguera, G.J., et al.

Nitric oxide binding to ferric cytochrome P450: A computational study
por: Cymeryng, Cora Beatriz, et al.
Publicado: (2000)

Nitric oxide binding to ferric cytochrome P450: A computational study
por: Scherlis, D.A., et al.

1-(Fluoroalkylidene)-1,1-bisphosphonic acids are potent and selective inhibitors of the enzymatic activity of Toxoplasma gondii farnesyl pyrophosphate synthase
por: Szajnman, Sergio Hernán, et al.
Publicado: (2012)

1-(Fluoroalkylidene)-1,1-bisphosphonic acids are potent and selective inhibitors of the enzymatic activity of Toxoplasma gondii farnesyl pyrophosphate synthase
por: Szajnman, S.H., et al.

Characterization of the farnesyl pyrophosphate synthase of Trypanosoma cruzi by homology modeling and molecular dynamics
por: Sigman, Lucas, et al.
Publicado: (2006)

Characterization of the farnesyl pyrophosphate synthase of Trypanosoma cruzi by homology modeling and molecular dynamics
por: Sigman, L., et al.

Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase
por: Szajnman, Sergio Hernán, et al.
Publicado: (2003)

Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase
por: Szajnman, S.H., et al.

Antiparasitic activity of sulfur- and fluorine-containing bisphosphonates against trypanosomatids and apicomplexan parasites
por: Szajnman, Sergio Hernán, et al.
Publicado: (2017)

Antiparasitic activity of sulfur- and fluorine-containing bisphosphonates against trypanosomatids and apicomplexan parasites
por: Galaka, T., et al.

Design, synthesis, and biological evaluation of aryloxyethyl thiocyanate derivatives against Trypanosoma cruzi
por: Elhalem, Eleonora, et al.
Publicado: (2002)

Design, synthesis, and biological evaluation of aryloxyethyl thiocyanate derivatives against Trypanosoma cruzi
por: Elhalem, E., et al.

Evidence of promising biological-pharmacological activities of the sertraline-based copper complex: (SerH<SUB>2</SUB>)<SUB>2</SUB>[CuCl<SUB>4</SUB>]
por: Martini, Nancy, et al.
Publicado: (2017)

Design, synthesis, and anti‐ Trypanosoma cruzi evaluation of a new class of cell‐growth inhibitors structurally related to Fenoxycarb
por: Schvartzapel, Andrea Judith, et al.
Publicado: (1995)

Design, synthesis, and anti‐ Trypanosoma cruzi evaluation of a new class of cell‐growth inhibitors structurally related to Fenoxycarb
por: Schvartzapel, A.J., et al.

Continuous nonradioactive method for screening trypanosomal transsialidase activity and its inhibitors
por: Agustí, Rosalía, et al.
Publicado: (2010)

Continuous nonradioactive method for screening trypanosomal transsialidase activity and its inhibitors
por: Sartor, P.A., et al.
Publicado: (2010)

Continuous nonradioactive method for screening trypanosomal transsialidase activity and its inhibitors
por: Sartor, P.A., et al.

Continuous nonradioactive method for screening trypanosomal transsialidase activity and its inhibitors
por: Sartor, P.A., et al.
Publicado: (2010)

Lactose derivatives are inhibitors of Trypanosoma cruzi trans-sialidase activity toward conventional substrates in vitro and in vivo
por: Agustí, Rosalía, et al.
Publicado: (2004)

Lactose derivatives are inhibitors of Trypanosoma cruzi trans-sialidase activity toward conventional substrates in vitro and in vivo
por: Agustí, R., et al.
Publicado: (2004)

Lactose derivatives are inhibitors of Trypanosoma cruzi trans-sialidase activity toward conventional substrates in vitro and in vivo
por: Agustí, R., et al.

Lactose derivatives are inhibitors of Trypanosoma cruzi trans-sialidase activity toward conventional substrates in vitro and in vivo
por: Agustí, R., et al.
Publicado: (2004)

Characterization of the catalytic subunit of Trypanosoma cruzi cyclic AMP-dependent protein kinase
por: Ochatt, Claudia Margarita, et al.
Publicado: (1993)

Characterization of the catalytic subunit of Trypanosoma cruzi cyclic AMP-dependent protein kinase
por: Ochatt, C.M., et al.

Synthesis of PEGylated lactose analogs for inhibition studies on T.cruzi trans-sialidase
por: Giorgi, María Eugenia, et al.
Publicado: (2010)

Synthesis of PEGylated lactose analogs for inhibition studies on T.cruzi trans-sialidase
por: Giorgi, M.E., et al.

New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase
por: Stortz, Carlos Arturo, et al.
Publicado: (2014)