Ligand migration in the apolar tunnel of Cerebratulus lacteus mini-hemoglobin

The large apolar tunnel traversing the mini-hemoglobin from Cerebratulus lacteus (CerHb) has been examined by xray crystallography, ligand binding kinetics, and molecular dynamic simulations. The addition of 10 atm of xenon causes loss of diffraction in wild-type (wt) CerHbO2 crystals, but Leu-86(G1...

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Guardado en:
Detalles Bibliográficos
Publicado: 2011
Materias:
Amide side chain
Bimolecular rate constants
CO Rebinding
Heme iron
Ligand binding
Ligand movement
Low energies
Molecular dynamic simulations
Molecular dynamics simulations
Wild types
Xenon atoms
Amides
Computer simulation
Crystallography
Hemoglobin
Internet protocols
Molecular dynamics
Porphyrins
Rate constants
Ligands
ligand
article
binding kinetics
cell migration
Cerebratulus lacteus
controlled study
crystallization
dissociation
equilibrium constant
gene mutation
genetic recombination
hydrogen bond
ligand binding
molecular dynamics
Nemertea
nonhuman
oxidation
photolysis
priority journal
protein conformation
thermodynamics
X ray crystallography
X ray diffraction
Animals
Computer Simulation
Crystallography, X-Ray
Heme
Hemoglobins
Invertebrates
Iron
Kinetics
Models, Molecular
Mutation, Missense
Protein Structure, Tertiary
Thermodynamics
Xenon
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00219258_v286_n7_p5347_Pesce
http://hdl.handle.net/20.500.12110/paper_00219258_v286_n7_p5347_Pesce
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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