c-Jun regulates phosphoinositide-dependent kinase 1 transcription: Implication for Akt and protein kinase C activities melanoma tumorigenesis

Mutations in N-RAS and B-RAF, which commonly occur in melanomas, result in constitutive activation of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated protein kinase (ERK) signaling. Active ERK increases expression and activity of the c-Jun transcription factor, linking ERK...

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Detalles Bibliográficos
Publicado:	2010
Materias:	Extracellular signal-regulated protein kinase Jun N-terminal kinase Melanoma cells Mitogen activated protein kinase Oncogenic activities Phosphoinositide-dependent kinase 1 Protein kinase c activities Transcriptional regulator Tumorigenesis Up-regulation Cell culture Dermatology Enzyme activity Phosphorylation Transcription Transcription factors Oncology phosphoinositide dependent protein kinase 1 protein c jun protein kinase B protein kinase C animal experiment animal model article carcinogenesis controlled study enzyme activity enzyme phosphorylation human human cell melanoma mouse nonhuman priority journal protein function regulatory mechanism transcription regulation tumor growth upregulation Animals Cell Line, Tumor Extracellular Signal-Regulated MAP Kinases Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans JNK Mitogen-Activated Protein Kinases MAP Kinase Signaling System Melanoma Mice Mice, Nude Neoplasm Transplantation Protein-Serine-Threonine Kinases Proto-Oncogene Proteins c-akt Proto-Oncogene Proteins c-jun Transcription, Genetic Transplantation, Heterologous Mus
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00219258_v285_n2_p903_LopezBergami http://hdl.handle.net/20.500.12110/paper_00219258_v285_n2_p903_LopezBergami
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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