Inhibitory effect of AP-1 complex on 5-aminolevulinate synthase gene expression through sequestration of cAMP-response element protein (CRE)-binding protein (CBP) coactivator

Activation protein-1 (AP-1) transcription factors are early response genes involved in a diverse set of transcriptional regulatory processes. The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) is often used to induce AP-1 activity. The purpose of this work was to explore the molecular mech...

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Detalles Bibliográficos
Autores principales:	Guberman, Alejandra Sonia, Scassa, María Elida, Giono, Luciana Eugenia, Varone, Cecilia Laura, Cánepa, Eduardo Tomás
Publicado:	2003
Materias:	Bioassay Biosynthesis Cloning Esters Proteins Molecular mechanisms Genes 5 aminolevulinate synthase chloramphenicol acetyltransferase cyclic AMP responsive element binding protein heme phorbol 13 acetate 12 myristate RNA stress activated protein kinase transcription factor transcription factor AP 1 calphostin C CREBBP protein, human cyclic AMP cyclic AMP responsive element binding protein binding protein messenger RNA naphthalene derivative nuclear protein protein c fos transactivator protein article biosynthesis controlled study cyclic AMP responsive element DNA flanking region early response gene gene expression genetic transcription hepatoma cell human human cell Northern blotting plasmid priority journal promoter region reporter gene transcription regulation biological model cell culture dimerization dominant gene dose response gene deletion gene vector genetic transfection genetics metabolism molecular cloning protein binding serodiagnosis site directed mutagenesis time Western blotting Butea monosperma Felis catus vectors 5-Aminolevulinate Synthetase Blotting, Western Cloning, Molecular CREB-Binding Protein Cyclic AMP Dimerization Dose-Response Relationship, Drug Gene Deletion Genes, Dominant Genes, Reporter Genetic Vectors Humans Models, Biological Mutagenesis, Site-Directed Naphthalenes Nuclear Proteins Precipitin Tests Promoter Regions (Genetics) Protein Binding Proto-Oncogene Proteins c-fos RNA, Messenger Time Factors Trans-Activators Transcription Factor AP-1 Transcription, Genetic Transfection Tumor Cells, Cultured
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00219258_v278_n4_p2317_Guberman http://hdl.handle.net/20.500.12110/paper_00219258_v278_n4_p2317_Guberman
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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