Coordination between transcription and pre-mRNA processing

A large body of work has proved that transcription by RNA polymerase II and pre-mRNA processing are coordinated events within the cell nucleus. Capping, splicing and polyadenylation occur while transcription proceeds, suggesting that RNA polymerase II plays a role in the regulation of these events....

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Autores principales: Cramer, Paula, Srebrow, Anabella, Kadener, Sebastián, de la Mata, Manuel, Melen, Gustavo Javier, Nogués, Guadalupe, Kornblihtt, Alberto Rodolfo
Publicado: 2001
Materias:
Carboxy-terminal domain
Coupling
mRNA processing
RNA polymerase II
messenger RNA
capping phenomenon
carboxy terminal sequence
cell nucleus
nonhuman
phosphorylation
polyadenylation
priority journal
promoter region
RNA processing
RNA splicing
RNA transcription
short survey
spliceosome
transcription regulation
Humans
Macromolecular Substances
Models, Biological
RNA Polymerase II
RNA Precursors
RNA Processing, Post-Transcriptional
RNA Splicing
Transcription, Genetic
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v498_n2-3_p179_Cramer
http://hdl.handle.net/20.500.12110/paper_00145793_v498_n2-3_p179_Cramer
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_00145793_v498_n2-3_p179_Cramer
record_format dspace
spelling paper:paper_00145793_v498_n2-3_p179_Cramer2025-07-30T17:20:21Z Coordination between transcription and pre-mRNA processing Cramer, Paula Srebrow, Anabella Kadener, Sebastián de la Mata, Manuel Melen, Gustavo Javier Nogués, Guadalupe Kornblihtt, Alberto Rodolfo Carboxy-terminal domain Coupling mRNA processing RNA polymerase II messenger RNA RNA polymerase II capping phenomenon carboxy terminal sequence cell nucleus nonhuman phosphorylation polyadenylation priority journal promoter region RNA processing RNA splicing RNA transcription short survey spliceosome transcription regulation Humans Macromolecular Substances Models, Biological RNA Polymerase II RNA Precursors RNA Processing, Post-Transcriptional RNA Splicing Transcription, Genetic A large body of work has proved that transcription by RNA polymerase II and pre-mRNA processing are coordinated events within the cell nucleus. Capping, splicing and polyadenylation occur while transcription proceeds, suggesting that RNA polymerase II plays a role in the regulation of these events. The presence and degree of phosphorylation of the carboxy-terminal domain of RNA polymerase II large subunit is important for functioning of the capping enzymes, the assembly of spliceosomes and the binding of the cleavage/polyadenylation complex. Nuclear architecture and gene promoter structure have also been shown to play key roles in coupling between transcription and splicing. © 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies. Fil:Cramer, P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Srebrow, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kadener, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:De La Mata, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Melen, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Nogués, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2001 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v498_n2-3_p179_Cramer http://hdl.handle.net/20.500.12110/paper_00145793_v498_n2-3_p179_Cramer
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Carboxy-terminal domain
Coupling
mRNA processing
RNA polymerase II
messenger RNA
RNA polymerase II
capping phenomenon
carboxy terminal sequence
cell nucleus
nonhuman
phosphorylation
polyadenylation
priority journal
promoter region
RNA processing
RNA splicing
RNA transcription
short survey
spliceosome
transcription regulation
Humans
Macromolecular Substances
Models, Biological
RNA Polymerase II
RNA Precursors
RNA Processing, Post-Transcriptional
RNA Splicing
Transcription, Genetic
spellingShingle Carboxy-terminal domain
Coupling
mRNA processing
RNA polymerase II
messenger RNA
RNA polymerase II
capping phenomenon
carboxy terminal sequence
cell nucleus
nonhuman
phosphorylation
polyadenylation
priority journal
promoter region
RNA processing
RNA splicing
RNA transcription
short survey
spliceosome
transcription regulation
Humans
Macromolecular Substances
Models, Biological
RNA Polymerase II
RNA Precursors
RNA Processing, Post-Transcriptional
RNA Splicing
Transcription, Genetic
Cramer, Paula
Srebrow, Anabella
Kadener, Sebastián
de la Mata, Manuel
Melen, Gustavo Javier
Nogués, Guadalupe
Kornblihtt, Alberto Rodolfo
Coordination between transcription and pre-mRNA processing
topic_facet Carboxy-terminal domain
Coupling
mRNA processing
RNA polymerase II
messenger RNA
RNA polymerase II
capping phenomenon
carboxy terminal sequence
cell nucleus
nonhuman
phosphorylation
polyadenylation
priority journal
promoter region
RNA processing
RNA splicing
RNA transcription
short survey
spliceosome
transcription regulation
Humans
Macromolecular Substances
Models, Biological
RNA Polymerase II
RNA Precursors
RNA Processing, Post-Transcriptional
RNA Splicing
Transcription, Genetic
description A large body of work has proved that transcription by RNA polymerase II and pre-mRNA processing are coordinated events within the cell nucleus. Capping, splicing and polyadenylation occur while transcription proceeds, suggesting that RNA polymerase II plays a role in the regulation of these events. The presence and degree of phosphorylation of the carboxy-terminal domain of RNA polymerase II large subunit is important for functioning of the capping enzymes, the assembly of spliceosomes and the binding of the cleavage/polyadenylation complex. Nuclear architecture and gene promoter structure have also been shown to play key roles in coupling between transcription and splicing. © 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
author Cramer, Paula
Srebrow, Anabella
Kadener, Sebastián
de la Mata, Manuel
Melen, Gustavo Javier
Nogués, Guadalupe
Kornblihtt, Alberto Rodolfo
author_facet Cramer, Paula
Srebrow, Anabella
Kadener, Sebastián
de la Mata, Manuel
Melen, Gustavo Javier
Nogués, Guadalupe
Kornblihtt, Alberto Rodolfo
author_sort Cramer, Paula
title Coordination between transcription and pre-mRNA processing
title_short Coordination between transcription and pre-mRNA processing
title_full Coordination between transcription and pre-mRNA processing
title_fullStr Coordination between transcription and pre-mRNA processing
title_full_unstemmed Coordination between transcription and pre-mRNA processing
title_sort coordination between transcription and pre-mrna processing
publishDate 2001
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v498_n2-3_p179_Cramer
http://hdl.handle.net/20.500.12110/paper_00145793_v498_n2-3_p179_Cramer
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AT srebrowanabella coordinationbetweentranscriptionandpremrnaprocessing
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AT delamatamanuel coordinationbetweentranscriptionandpremrnaprocessing
AT melengustavojavier coordinationbetweentranscriptionandpremrnaprocessing
AT noguesguadalupe coordinationbetweentranscriptionandpremrnaprocessing
AT kornblihttalbertorodolfo coordinationbetweentranscriptionandpremrnaprocessing
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