Prostaglandin F2α decreases the affinity of epidermal growth factor receptors in Swiss mouse 3T3 cells via protein kinase C activation

Prostaglandin F2α (PGF2α) selectively decreases the binding of 125I-labelled epidermal growth factor ([125I]EGF) to intact Swiss 3T3 cells. Scatchard analysis reveals that PGF2α decreases the number of high-affinity EGF binding sites without changing the total number of receptors. Prostaglandins E1...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado: 1992
Materias:
Diacylglycerol
DNA synthesis
Epidermal growth factor receptor
Prostaglandin F2α
Protein kinase C
Swiss 3T3 cells
3 [2 [4 (4,4' difluorobenzhydrylidene)piperidino]ethyl] 2,3 dihydro 2 thioxo 4(1h) quinazolinone
6 [2 [4 [(4 fluorophenyl)phenylmethylene] 1 piperidyl]ethyl] 7 methyl 5h thiazolo[3,2 a]pyrimidin 5 one
enzyme inhibitor
epidermal growth factor
epidermal growth factor receptor
prostaglandin derivative
prostaglandin f2 alpha
protein kinase c
diacylglycerol kinase
phosphotransferase
prostaglandin E
prostaglandin F2 alpha
protein kinase C
animal cell
article
binding affinity
enzyme activation
mouse
nonhuman
priority journal
receptor binding
animal
cell strain 3T3
dose response
drug effect
metabolism
sensitivity and specificity
3T3 Cells
Animal
Diacylglycerol Kinase
Dinoprost
Dose-Response Relationship, Drug
Enzyme Activation
Epidermal Growth Factor
Mice
Phosphotransferases
Prostaglandins E
Protein Kinase C
Receptor, Epidermal Growth Factor
Sensitivity and Specificity
Support, Non-U.S. Gov't
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v299_n3_p235_deAsua
http://hdl.handle.net/20.500.12110/paper_00145793_v299_n3_p235_deAsua
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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