A novel mechanism of resistance to α-difluoromethylornithine induced by cycloheximide. Growth with abnormally low levels of putrescine and spermidine

Treatment of the chemically transformed fibroblasts BP-A31 and other cell lines with low concentrations of cycloheximide (CHM) for 72 h followed by the removal of the protein synthesis inhibitor leads to the proliferation of α-difluoromethylornithine (DFMO)-resistant phenotypes. These drug-resistant...

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Detalles Bibliográficos
Autores principales:	Lauinger de Medrano, Estela E., Burrone, Oscar R., Ferrer, Marcela María, Algranati, Israel David
Publicado:	1986
Materias:	Cycloheximide Ornithine decarboxylase Polyamine α-Difluoromethylornithine resistance cycloheximide eflornithine putrescine spermidine cell line drug inhibition drug resistance fibroblast in vitro study nonhuman priority journal Animals Cell Line Drug Resistance Eflornithine Fibroblasts Humans Mice Ornithine Decarboxylase Putrescine Spermidine
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v206_n1_p106_Medrano http://hdl.handle.net/20.500.12110/paper_00145793_v206_n1_p106_Medrano
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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