Effect of alloimmunized thymic cells on isolated mouse atria. Participation of prostaglandins

The effects of thymic cells from alloimmunized mice on the mechanical activity of isolated mouse atria were explored. Immune cells decreased the tension without changing the rate of beating of the atrium. After inhibition of prostaglandin synthesis with indomethacin and acetylsalicylic acid, the neg...

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Detalles Bibliográficos
Publicado: 1983
Materias:
acetylsalicylic acid
indometacin
mepyramine
prostaglandin
animal cell
drug efficacy
heart
heart atrium
mouse
nonhuman
Animal
Aspirin
Depression, Chemical
Dose-Response Relationship, Drug
Heart Atrium
Indomethacin
Isoantibodies
Mice
Mice, Inbred BALB C
Myocardial Contraction
Pyrilamine
Support, Non-U.S. Gov't
T-Lymphocytes
Time Factors
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00144754_v39_n9_p1033_Genaro
http://hdl.handle.net/20.500.12110/paper_00144754_v39_n9_p1033_Genaro
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The effects of thymic cells from alloimmunized mice on the mechanical activity of isolated mouse atria were explored. Immune cells decreased the tension without changing the rate of beating of the atrium. After inhibition of prostaglandin synthesis with indomethacin and acetylsalicylic acid, the negative inotropic action of alloimmunized thymic cells was blocked. © 1983 Birkhäuser Verlag.

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