Effect of naloxone on the nocturnal rise of rat pineal melatonin content
Rats exposed to 14 light: 10 h dark photoperiods were given naloxone hydrochloride (10 mg/kg) s.c. 2 h before and 5 h after the lights were turned off. A smaller noctúrnal pineal melatonin peak, as well as a slower decrease from peak values were observed in naloxone-treated rats. Naloxone (up to 10-...
Guardado en:
| Publicado: |
1984
|
|---|---|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00142999_v98_n2_p261_Lowenstein http://hdl.handle.net/20.500.12110/paper_00142999_v98_n2_p261_Lowenstein |
| Aporte de: |
| Sumario: | Rats exposed to 14 light: 10 h dark photoperiods were given naloxone hydrochloride (10 mg/kg) s.c. 2 h before and 5 h after the lights were turned off. A smaller noctúrnal pineal melatonin peak, as well as a slower decrease from peak values were observed in naloxone-treated rats. Naloxone (up to 10-4M) did not affect either in vitro rat pineal melatonin content or 3H-labeled transmitter release in glands previously incubated with [3H]norepinephrine. Hence a central, rather than a peripheral opioid synapse appears to be involved in naloxone effect on nocturnal melatonin increase. © 1984. |
|---|