Sex differences in the pituitary transforming growth factor-β1 system: Studies in a model of resistant prolactinomas

Dopamine and estradiol interact in the regulation of lactotroph cell proliferation and prolactin secretion. Ablation of the dopamine D2 receptor gene (Drd2-/-) in mice leads to a sexually dimorphic phenotype of hyperprolactinemia and pituitary hyperplasia, which is stronger in females. TGF-β1 is a k...

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Detalles Bibliográficos
Publicado:	2013
Materias:	binding protein dopamine estrogen furin kallikrein kallikrein 1 matrix metalloproteinase thrombospondin 1 transforming growth factor beta binding protein transforming growth factor beta1 unclassified drug animal experiment animal model article controlled study down regulation female gene expression genotype hypophysis male mouse nonhuman priority journal prolactinoma sex difference Animals Female Gene Expression Regulation Genotype Integrins Male Mice Mice, Knockout Pituitary Gland Pituitary Neoplasms Prolactinoma Receptors, Dopamine D2 Sex Factors Thrombospondin 1 Tissue Kallikreins Transforming Growth Factor beta1
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00137227_v154_n11_p4192_Recouvreux http://hdl.handle.net/20.500.12110/paper_00137227_v154_n11_p4192_Recouvreux
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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