A microscopic study of the deoxyhemoglobin-catalyzed generation of nitric oxide from nitrite anion

There is recent evidence suggesting that nitrite anion (NO2 -) represents the major intravascular NO storage molecule whose transduction to NO is facilitated by a reduction mechanism catalyzed by deoxygenated hemoglobin (deoxy-Hb). In this work, we provide a detailed microscopic study of deoxy-Hb ni...

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Detalles Bibliográficos
Autores principales:	Perissinotti, Laura L., Martí, Marcelo Adrián, Doctorovich, Fabio Ariel, Estrin, Dario Ariel
Publicado:	2008
Materias:	Nitric oxide Deoxy hemoglobin Microscopic study Nitric oxides Nitrite anion Negative ions deoxyhemoglobin ferric ion heme histidine methemoglobin nitric oxide nitrite nitrite reductase nitrogen nitrous acid oxygen article catalysis complex formation enzyme activity human molecular dynamics priority journal proton transport quantum mechanics Anions Binding Sites Catalysis Hemoglobins Histidine Humans Ligands Models, Molecular Nitric Oxide Nitrite Reductases Nitrites Protein Conformation Bacteria (microorganisms)
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062960_v47_n37_p9793_Perissinotti http://hdl.handle.net/20.500.12110/paper_00062960_v47_n37_p9793_Perissinotti
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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