Antiviral activity of a sulphated polysaccharide from the red seaweed nothogenia fastigiata

The antiviral activity of polysaccharide fractions obtained from water extracts of the red seaweed Nothogenia fastigiata was investigated. Fraction F6, corresponding to a sulphated xylomannan, was found to inhibit efficiently the replication of herpes simplex virus type 1 (HSV-1). Furthermore, F6 se...

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Autores principales: Damonte, Elsa Beatriz, Pujol, Carlos Alberto, Andrei, Graciela Mónica, Matulewicz, María Cristina, Cerezo, Alberto Saúl, Coto, Celia Esther
Publicado: 1994
Materias:
antiviral
HCMV
HIV
HSV
influenza virus
sulphated polymers
antivirus agent
plant extract
polysaccharide sulfate
virus dna
virus rna
animal cell
antiviral activity
article
concentration response
cytomegalovirus
drug cytotoxicity
drug isolation
herpes simplex virus 1
human
human cell
human immunodeficiency virus 1
human immunodeficiency virus 2
human immunodeficiency virus infection
influenza virus a
influenza virus b
junin virus
nonhuman
priority journal
respiratory syncytial pneumovirus
seaweed
simian immunodeficiency virus
virus adsorption
virus inhibition
virus replication
Antiviral Agents
Chemical Fractionation
Herpesvirus 1, Human
Microbial Sensitivity Tests
Polysaccharides
Seaweed
Support, Non-U.S. Gov't
Virus Replication
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062952_v47_n12_p2187_Damonte
http://hdl.handle.net/20.500.12110/paper_00062952_v47_n12_p2187_Damonte
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_00062952_v47_n12_p2187_Damonte
record_format dspace
spelling paper:paper_00062952_v47_n12_p2187_Damonte2023-06-08T14:30:33Z Antiviral activity of a sulphated polysaccharide from the red seaweed nothogenia fastigiata Damonte, Elsa Beatriz Pujol, Carlos Alberto Andrei, Graciela Mónica Matulewicz, María Cristina Cerezo, Alberto Saúl Coto, Celia Esther antiviral HCMV HIV HSV influenza virus sulphated polymers antivirus agent plant extract polysaccharide sulfate virus dna virus rna animal cell antiviral activity article concentration response cytomegalovirus drug cytotoxicity drug isolation herpes simplex virus 1 human human cell human immunodeficiency virus 1 human immunodeficiency virus 2 human immunodeficiency virus infection influenza virus a influenza virus b junin virus nonhuman priority journal respiratory syncytial pneumovirus seaweed simian immunodeficiency virus virus adsorption virus inhibition virus replication Antiviral Agents Chemical Fractionation Herpesvirus 1, Human Microbial Sensitivity Tests Polysaccharides Seaweed Support, Non-U.S. Gov't Virus Replication The antiviral activity of polysaccharide fractions obtained from water extracts of the red seaweed Nothogenia fastigiata was investigated. Fraction F6, corresponding to a sulphated xylomannan, was found to inhibit efficiently the replication of herpes simplex virus type 1 (HSV-1). Furthermore, F6 selectively inhibited the replication of several other enveloped viruses including herpes simplex virus type 2, human cytomegalovirus (HCMV), respiratory syncytial virus, influenza A and B virus, Junin and Tacaribe virus and simian immunodeficiency virus. F6 was only weakly active against human immunodeficiency virus type 1 and 2. The mode of action of F6 against HSV-1 and HCMV could be ascribed to an inhibitory effect on virus adsorption. © 1994. Fil:Damonte, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pujol, C.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Andrei, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Matulewicz, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cerezo, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Coto, C.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1994 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062952_v47_n12_p2187_Damonte http://hdl.handle.net/20.500.12110/paper_00062952_v47_n12_p2187_Damonte
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic antiviral
HCMV
HIV
HSV
influenza virus
sulphated polymers
antivirus agent
plant extract
polysaccharide sulfate
virus dna
virus rna
animal cell
antiviral activity
article
concentration response
cytomegalovirus
drug cytotoxicity
drug isolation
herpes simplex virus 1
human
human cell
human immunodeficiency virus 1
human immunodeficiency virus 2
human immunodeficiency virus infection
influenza virus a
influenza virus b
junin virus
nonhuman
priority journal
respiratory syncytial pneumovirus
seaweed
simian immunodeficiency virus
virus adsorption
virus inhibition
virus replication
Antiviral Agents
Chemical Fractionation
Herpesvirus 1, Human
Microbial Sensitivity Tests
Polysaccharides
Seaweed
Support, Non-U.S. Gov't
Virus Replication
spellingShingle antiviral
HCMV
HIV
HSV
influenza virus
sulphated polymers
antivirus agent
plant extract
polysaccharide sulfate
virus dna
virus rna
animal cell
antiviral activity
article
concentration response
cytomegalovirus
drug cytotoxicity
drug isolation
herpes simplex virus 1
human
human cell
human immunodeficiency virus 1
human immunodeficiency virus 2
human immunodeficiency virus infection
influenza virus a
influenza virus b
junin virus
nonhuman
priority journal
respiratory syncytial pneumovirus
seaweed
simian immunodeficiency virus
virus adsorption
virus inhibition
virus replication
Antiviral Agents
Chemical Fractionation
Herpesvirus 1, Human
Microbial Sensitivity Tests
Polysaccharides
Seaweed
Support, Non-U.S. Gov't
Virus Replication
Damonte, Elsa Beatriz
Pujol, Carlos Alberto
Andrei, Graciela Mónica
Matulewicz, María Cristina
Cerezo, Alberto Saúl
Coto, Celia Esther
Antiviral activity of a sulphated polysaccharide from the red seaweed nothogenia fastigiata
topic_facet antiviral
HCMV
HIV
HSV
influenza virus
sulphated polymers
antivirus agent
plant extract
polysaccharide sulfate
virus dna
virus rna
animal cell
antiviral activity
article
concentration response
cytomegalovirus
drug cytotoxicity
drug isolation
herpes simplex virus 1
human
human cell
human immunodeficiency virus 1
human immunodeficiency virus 2
human immunodeficiency virus infection
influenza virus a
influenza virus b
junin virus
nonhuman
priority journal
respiratory syncytial pneumovirus
seaweed
simian immunodeficiency virus
virus adsorption
virus inhibition
virus replication
Antiviral Agents
Chemical Fractionation
Herpesvirus 1, Human
Microbial Sensitivity Tests
Polysaccharides
Seaweed
Support, Non-U.S. Gov't
Virus Replication
description The antiviral activity of polysaccharide fractions obtained from water extracts of the red seaweed Nothogenia fastigiata was investigated. Fraction F6, corresponding to a sulphated xylomannan, was found to inhibit efficiently the replication of herpes simplex virus type 1 (HSV-1). Furthermore, F6 selectively inhibited the replication of several other enveloped viruses including herpes simplex virus type 2, human cytomegalovirus (HCMV), respiratory syncytial virus, influenza A and B virus, Junin and Tacaribe virus and simian immunodeficiency virus. F6 was only weakly active against human immunodeficiency virus type 1 and 2. The mode of action of F6 against HSV-1 and HCMV could be ascribed to an inhibitory effect on virus adsorption. © 1994.
author Damonte, Elsa Beatriz
Pujol, Carlos Alberto
Andrei, Graciela Mónica
Matulewicz, María Cristina
Cerezo, Alberto Saúl
Coto, Celia Esther
author_facet Damonte, Elsa Beatriz
Pujol, Carlos Alberto
Andrei, Graciela Mónica
Matulewicz, María Cristina
Cerezo, Alberto Saúl
Coto, Celia Esther
author_sort Damonte, Elsa Beatriz
title Antiviral activity of a sulphated polysaccharide from the red seaweed nothogenia fastigiata
title_short Antiviral activity of a sulphated polysaccharide from the red seaweed nothogenia fastigiata
title_full Antiviral activity of a sulphated polysaccharide from the red seaweed nothogenia fastigiata
title_fullStr Antiviral activity of a sulphated polysaccharide from the red seaweed nothogenia fastigiata
title_full_unstemmed Antiviral activity of a sulphated polysaccharide from the red seaweed nothogenia fastigiata
title_sort antiviral activity of a sulphated polysaccharide from the red seaweed nothogenia fastigiata
publishDate 1994
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062952_v47_n12_p2187_Damonte
http://hdl.handle.net/20.500.12110/paper_00062952_v47_n12_p2187_Damonte
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