1-Cinnamoyl-3,11-dihydroxymeliacarpin delays glycoprotein transport restraining virus multiplication without cytotoxicity

The 1-cinnamoyl-3,11-dihydroxymeliacarpin (CDM), isolated from extracts of Melia azedarach L., displays antiviral and immunomodulating properties. CDM is the first reported tetranortriterpenoid responsible for the alkalinization of intracellular compartments affecting both, viral endocytic and exocy...

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Detalles Bibliográficos
Autores principales: Bueno, Carlos Alberto, Alche, Laura Edith, Barquero, Andrea Alejandra
Publicado: 2010
Materias:
Antiviral
Golgi apparatus
Medicinal plants
Secretory pathway
Transferrin receptor
1 cinnamoyl 3,11 dihydroxymeliacarpin
concanamycin A
glycoprotein
Melia azedarach extract
monensin
transferrin receptor
triterpenoid
unclassified drug
alkalinization
article
cell compartmentalization
cell membrane
controlled study
cytotoxicity
drug activity
drug inhibition
endosome
glycoprotein synthesis
Herpes simplex virus 1
human
human cell
immunomodulation
integument
Melia azedarach
membrane transport
nonhuman
priority journal
protein binding
protein localization
protein transport
virogenesis
virus capsid
Antiviral Agents
Cell Line
Glycoproteins
Herpesvirus 1, Human
Humans
Limonins
Macrolides
Monensin
Protein Transport
Receptors, Transferrin
Tumor Necrosis Factor-alpha
Viral Envelope Proteins
Virus Replication
Human herpesvirus 1
Miridae
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v393_n1_p32_Bueno
http://hdl.handle.net/20.500.12110/paper_0006291X_v393_n1_p32_Bueno
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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