Antibacterial activity of the plant-derived compounds 23-methyl-6- O -desmethylauricepyrone and (Z, Z)-5-(trideca-4,7-dienyl)resorcinol and their synergy with antibiotics against methicillin-susceptible and -resistant Staphylococcus aureus

The present study investigated the antibacterial activity of two plant-derived compounds, 23-methyl-6-O-desmethylauricepyrone (1) and (Z,Z)-5-(trideca-4,7-dienyl)resorcinol (2), and their synergistic effects with erythromycin and gentamicin against methicillin-susceptible (MSSA) and gentamicin- and...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Joray, Mariana Belén, Gonzalez, María Laura, Palacios, Sara María, Carpinella, María Cecilia
Formato: Artículo PeerReviewed
Lenguaje:Español
Publicado: 2011
Materias:
QD Química
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/5020/1/A_Joray.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-5020
record_format dspace
spelling I38-R144-50202025-11-13T14:12:26Z http://pa.bibdigital.ucc.edu.ar/5020/ Antibacterial activity of the plant-derived compounds 23-methyl-6- O -desmethylauricepyrone and (Z, Z)-5-(trideca-4,7-dienyl)resorcinol and their synergy with antibiotics against methicillin-susceptible and -resistant Staphylococcus aureus Joray, Mariana Belén Gonzalez, María Laura Palacios, Sara María Carpinella, María Cecilia QD Química The present study investigated the antibacterial activity of two plant-derived compounds, 23-methyl-6-O-desmethylauricepyrone (1) and (Z,Z)-5-(trideca-4,7-dienyl)resorcinol (2), and their synergistic effects with erythromycin and gentamicin against methicillin-susceptible (MSSA) and gentamicin- and methicillin-resistant Staphylococcus aureus (MRSA). Studies of the individual antibacterial activity of each plant-derived compound and synergy experiments were carried out, by the microdilution test in agar and by the checkerboard method, respectively. Compound 1 showed minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 2 and 8 μg/mL, respectively, against both strains of S. aureus, while compound 2 exhibited anti-MSSA and anti-MRSA activity with MICs and MBCs of 4 and 8 and 2 and 8 μg/mL, respectively. Time-kill curves showed that, while compound 1 produced complete killing of both strains at 24 h from the beginning of the experiment, 2 produced the same effect in the first hour. Combinations of 1 with erythromycin or gentamicin showed a notable synergism against MSSA, which enabled the antibiotic concentration to decrease by up to 300 or 260 times, respectively. When the aminoglycoside was placed together with compound 2, only an additive effect was observed. The assayed compounds did not produce erythrocyte hemolysis or genotoxicity and they did not affect macrophage viability at the effective or higher concentrations. These results suggest that both compounds could be considered as promising antibacterial agents while compound 1 could be used in combinatory therapies with erythromycin and gentamicin. 2011-12 Artículo PeerReviewed application/pdf spa http://pa.bibdigital.ucc.edu.ar/5020/1/A_Joray.pdf Joray, Mariana Belén ORCID: https://orcid.org/0000-0001-9042-6926 <https://orcid.org/0000-0001-9042-6926>, Gonzalez, María Laura ORCID: https://orcid.org/0000-0003-2111-7286 <https://orcid.org/0000-0003-2111-7286>, Palacios, Sara María and Carpinella, María Cecilia ORCID: https://orcid.org/0000-0001-5553-1851 <https://orcid.org/0000-0001-5553-1851> (2011) Antibacterial activity of the plant-derived compounds 23-methyl-6- O -desmethylauricepyrone and (Z, Z)-5-(trideca-4,7-dienyl)resorcinol and their synergy with antibiotics against methicillin-susceptible and -resistant Staphylococcus aureus. Journal of Agricultural and Food Chemistry, 59 (21). pp. 11534-11542. ISSN 0021-8561 info:eu-repo/semantics/altIdentifier/doi/10.1021/jf2030665
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic QD Química
spellingShingle QD Química
Joray, Mariana Belén
Gonzalez, María Laura
Palacios, Sara María
Carpinella, María Cecilia
Antibacterial activity of the plant-derived compounds 23-methyl-6- O -desmethylauricepyrone and (Z, Z)-5-(trideca-4,7-dienyl)resorcinol and their synergy with antibiotics against methicillin-susceptible and -resistant Staphylococcus aureus
topic_facet QD Química
description The present study investigated the antibacterial activity of two plant-derived compounds, 23-methyl-6-O-desmethylauricepyrone (1) and (Z,Z)-5-(trideca-4,7-dienyl)resorcinol (2), and their synergistic effects with erythromycin and gentamicin against methicillin-susceptible (MSSA) and gentamicin- and methicillin-resistant Staphylococcus aureus (MRSA). Studies of the individual antibacterial activity of each plant-derived compound and synergy experiments were carried out, by the microdilution test in agar and by the checkerboard method, respectively. Compound 1 showed minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 2 and 8 μg/mL, respectively, against both strains of S. aureus, while compound 2 exhibited anti-MSSA and anti-MRSA activity with MICs and MBCs of 4 and 8 and 2 and 8 μg/mL, respectively. Time-kill curves showed that, while compound 1 produced complete killing of both strains at 24 h from the beginning of the experiment, 2 produced the same effect in the first hour. Combinations of 1 with erythromycin or gentamicin showed a notable synergism against MSSA, which enabled the antibiotic concentration to decrease by up to 300 or 260 times, respectively. When the aminoglycoside was placed together with compound 2, only an additive effect was observed. The assayed compounds did not produce erythrocyte hemolysis or genotoxicity and they did not affect macrophage viability at the effective or higher concentrations. These results suggest that both compounds could be considered as promising antibacterial agents while compound 1 could be used in combinatory therapies with erythromycin and gentamicin.
format Artículo
PeerReviewed
author Joray, Mariana Belén
Gonzalez, María Laura
Palacios, Sara María
Carpinella, María Cecilia
author_facet Joray, Mariana Belén
Gonzalez, María Laura
Palacios, Sara María
Carpinella, María Cecilia
author_sort Joray, Mariana Belén
title Antibacterial activity of the plant-derived compounds 23-methyl-6- O -desmethylauricepyrone and (Z, Z)-5-(trideca-4,7-dienyl)resorcinol and their synergy with antibiotics against methicillin-susceptible and -resistant Staphylococcus aureus
title_short Antibacterial activity of the plant-derived compounds 23-methyl-6- O -desmethylauricepyrone and (Z, Z)-5-(trideca-4,7-dienyl)resorcinol and their synergy with antibiotics against methicillin-susceptible and -resistant Staphylococcus aureus
title_full Antibacterial activity of the plant-derived compounds 23-methyl-6- O -desmethylauricepyrone and (Z, Z)-5-(trideca-4,7-dienyl)resorcinol and their synergy with antibiotics against methicillin-susceptible and -resistant Staphylococcus aureus
title_fullStr Antibacterial activity of the plant-derived compounds 23-methyl-6- O -desmethylauricepyrone and (Z, Z)-5-(trideca-4,7-dienyl)resorcinol and their synergy with antibiotics against methicillin-susceptible and -resistant Staphylococcus aureus
title_full_unstemmed Antibacterial activity of the plant-derived compounds 23-methyl-6- O -desmethylauricepyrone and (Z, Z)-5-(trideca-4,7-dienyl)resorcinol and their synergy with antibiotics against methicillin-susceptible and -resistant Staphylococcus aureus
title_sort antibacterial activity of the plant-derived compounds 23-methyl-6- o -desmethylauricepyrone and (z, z)-5-(trideca-4,7-dienyl)resorcinol and their synergy with antibiotics against methicillin-susceptible and -resistant staphylococcus aureus
publishDate 2011
url http://pa.bibdigital.ucc.edu.ar/5020/1/A_Joray.pdf
work_keys_str_mv AT joraymarianabelen antibacterialactivityoftheplantderivedcompounds23methyl6odesmethylauricepyroneandzz5trideca47dienylresorcinolandtheirsynergywithantibioticsagainstmethicillinsusceptibleandresistantstaphylococcusaureus
AT gonzalezmarialaura antibacterialactivityoftheplantderivedcompounds23methyl6odesmethylauricepyroneandzz5trideca47dienylresorcinolandtheirsynergywithantibioticsagainstmethicillinsusceptibleandresistantstaphylococcusaureus
AT palaciossaramaria antibacterialactivityoftheplantderivedcompounds23methyl6odesmethylauricepyroneandzz5trideca47dienylresorcinolandtheirsynergywithantibioticsagainstmethicillinsusceptibleandresistantstaphylococcusaureus
AT carpinellamariacecilia antibacterialactivityoftheplantderivedcompounds23methyl6odesmethylauricepyroneandzz5trideca47dienylresorcinolandtheirsynergywithantibioticsagainstmethicillinsusceptibleandresistantstaphylococcusaureus
_version_ 1848831226496942080

Ejemplares similares