High-dose steroid treatment increases free water transport in peritoneal dialysis patients

The water channel aquaporin-1 (AQP1) is the molecular counterpart of the ultrasmall pore that mediates free water transport during peritoneal dialysis (PD). Proof-of-principle studies performed in rats have shown that treatment with corticosteroids upregulates the expression of AQP1 in the peritonea...

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Autores principales: De Arteaga, Javier, Ledesma, Fabián, Garay, Gabriela, Chiurchiu, Carlos, Fuente, Jorge de la, Douthat, Walter Guillermo, Massari, Pablo U., Terryn, Sara, Devuyst, Oliver
Formato: Artículo PeerReviewed
Lenguaje:Español
Publicado: 2011
Materias:
R Medicina (General)
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/5017/1/A_De%20Arteaga.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-5017
record_format dspace
spelling I38-R144-50172025-11-11T17:34:35Z http://pa.bibdigital.ucc.edu.ar/5017/ High-dose steroid treatment increases free water transport in peritoneal dialysis patients De Arteaga, Javier Ledesma, Fabián Garay, Gabriela Chiurchiu, Carlos Fuente, Jorge de la Douthat, Walter Guillermo Massari, Pablo U. Terryn, Sara Devuyst, Oliver R Medicina (General) The water channel aquaporin-1 (AQP1) is the molecular counterpart of the ultrasmall pore that mediates free water transport during peritoneal dialysis (PD). Proof-of-principle studies performed in rats have shown that treatment with corticosteroids upregulates the expression of AQP1 in the peritoneal capillaries, causing a significant increase in free water transport. Whether such a beneficial effect could be observed in end-stage renal disease patients treated by PD remains unknown. Peritoneal transport parameters were evaluated in three patients on PD, shortly before and after living-donor renal transplantation and treatment with high-dose methylprednisolone (1.0-1.2 g/m2). As compared with pre-transplantation values, the post-transplantation test revealed an ∼2-fold increase in the sodium sieving and ultrasmall pore ultrafiltration volume, suggesting an effect on AQP1 water channels. In contrast, there was no change in the parameters of small solute transport. The direct involvement of AQP1 in these changes is suggested by the expression of glucocorticoid receptors in the human peritoneum and the presence of conserved glucocorticoid response elements in the promoter of the human AQP1 gene. 2011-12-31 Artículo PeerReviewed application/pdf spa http://pa.bibdigital.ucc.edu.ar/5017/1/A_De%20Arteaga.pdf De Arteaga, Javier, Ledesma, Fabián, Garay, Gabriela, Chiurchiu, Carlos, Fuente, Jorge de la, Douthat, Walter Guillermo ORCID: https://orcid.org/0000-0002-4644-6003 <https://orcid.org/0000-0002-4644-6003>, Massari, Pablo U., Terryn, Sara and Devuyst, Oliver (2011) High-dose steroid treatment increases free water transport in peritoneal dialysis patients. Nephrology Dialysis Transplantation. pp. 4142-4145. ISSN 14602385 info:eu-repo/semantics/altIdentifier/doi/10.1093/ndt/gfr533
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic R Medicina (General)
spellingShingle R Medicina (General)
De Arteaga, Javier
Ledesma, Fabián
Garay, Gabriela
Chiurchiu, Carlos
Fuente, Jorge de la
Douthat, Walter Guillermo
Massari, Pablo U.
Terryn, Sara
Devuyst, Oliver
High-dose steroid treatment increases free water transport in peritoneal dialysis patients
topic_facet R Medicina (General)
description The water channel aquaporin-1 (AQP1) is the molecular counterpart of the ultrasmall pore that mediates free water transport during peritoneal dialysis (PD). Proof-of-principle studies performed in rats have shown that treatment with corticosteroids upregulates the expression of AQP1 in the peritoneal capillaries, causing a significant increase in free water transport. Whether such a beneficial effect could be observed in end-stage renal disease patients treated by PD remains unknown. Peritoneal transport parameters were evaluated in three patients on PD, shortly before and after living-donor renal transplantation and treatment with high-dose methylprednisolone (1.0-1.2 g/m2). As compared with pre-transplantation values, the post-transplantation test revealed an ∼2-fold increase in the sodium sieving and ultrasmall pore ultrafiltration volume, suggesting an effect on AQP1 water channels. In contrast, there was no change in the parameters of small solute transport. The direct involvement of AQP1 in these changes is suggested by the expression of glucocorticoid receptors in the human peritoneum and the presence of conserved glucocorticoid response elements in the promoter of the human AQP1 gene.
format Artículo
PeerReviewed
author De Arteaga, Javier
Ledesma, Fabián
Garay, Gabriela
Chiurchiu, Carlos
Fuente, Jorge de la
Douthat, Walter Guillermo
Massari, Pablo U.
Terryn, Sara
Devuyst, Oliver
author_facet De Arteaga, Javier
Ledesma, Fabián
Garay, Gabriela
Chiurchiu, Carlos
Fuente, Jorge de la
Douthat, Walter Guillermo
Massari, Pablo U.
Terryn, Sara
Devuyst, Oliver
author_sort De Arteaga, Javier
title High-dose steroid treatment increases free water transport in peritoneal dialysis patients
title_short High-dose steroid treatment increases free water transport in peritoneal dialysis patients
title_full High-dose steroid treatment increases free water transport in peritoneal dialysis patients
title_fullStr High-dose steroid treatment increases free water transport in peritoneal dialysis patients
title_full_unstemmed High-dose steroid treatment increases free water transport in peritoneal dialysis patients
title_sort high-dose steroid treatment increases free water transport in peritoneal dialysis patients
publishDate 2011
url http://pa.bibdigital.ucc.edu.ar/5017/1/A_De%20Arteaga.pdf
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