Screening for acetylcholinesterase inhibitory activity in plant extracts from Argentina

Plants are a potential source of bioactive compounds and offer a promising strategy for the treatment of neurological disorders such as Alzheimer's disease. The inhibitory effect of 73 native and naturalized plants collected from the central region of Argentina on acetylcholinesterase (AChE) wa...

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Autores principales: Carpinella, María Cecilia, Andrione, Diego Gabriel, Ruiz, Gustavo Miguel, Palacios, Sara M.
Formato: Artículo PeerReviewed
Lenguaje:Español
Publicado: 2010
Materias:
SF Cultura de los animales
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/5000/1/A_Carpinella.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-5000
record_format dspace
spelling I38-R144-50002025-11-06T16:42:23Z http://pa.bibdigital.ucc.edu.ar/5000/ Screening for acetylcholinesterase inhibitory activity in plant extracts from Argentina Carpinella, María Cecilia Andrione, Diego Gabriel Ruiz, Gustavo Miguel Palacios, Sara M. SF Cultura de los animales Plants are a potential source of bioactive compounds and offer a promising strategy for the treatment of neurological disorders such as Alzheimer's disease. The inhibitory effect of 73 native and naturalized plants collected from the central region of Argentina on acetylcholinesterase (AChE) was tested using microplate and TLC assays after solvent fractionation of complete ethanol extracts obtained from the plants. Organic fractions obtained from extracts of Achyrocline tomentosa (Asteraceae), Eupatorium viscidum (Asteraceae), Ruprechtia apetala (Polygonaceae) Trichocline reptans (Asteraceae) and Zanthoxylum coco (Rutaceae) presented strong inhibition of AChE (higher than 80%) at 1 mg/mL, with R. apetala and T. reptans being the most potent, showing complete inhibition of the enzyme. Their IC50 values were 0.0779 and 0.1118 mg/mL, respectively. Aqueous fractions did not show any inhibitory activity on the enzyme. These results suggest that the most effective extracts deserve further investigation with the aim of obtaining new molecules for the treatment of neurodegenerative disorders. 2010-12-31 Artículo PeerReviewed application/pdf spa http://pa.bibdigital.ucc.edu.ar/5000/1/A_Carpinella.pdf Carpinella, María Cecilia ORCID: https://orcid.org/0000-0001-5553-1851 <https://orcid.org/0000-0001-5553-1851>, Andrione, Diego Gabriel, Ruiz, Gustavo Miguel ORCID: https://orcid.org/0000-0002-0571-3224 <https://orcid.org/0000-0002-0571-3224> and Palacios, Sara M. (2010) Screening for acetylcholinesterase inhibitory activity in plant extracts from Argentina. Phytotherapy Research, 24 (2). pp. 259-263. ISSN 10991573 info:eu-repo/semantics/altIdentifier/doi/10.1002/ptr.2923
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic SF Cultura de los animales
spellingShingle SF Cultura de los animales
Carpinella, María Cecilia
Andrione, Diego Gabriel
Ruiz, Gustavo Miguel
Palacios, Sara M.
Screening for acetylcholinesterase inhibitory activity in plant extracts from Argentina
topic_facet SF Cultura de los animales
description Plants are a potential source of bioactive compounds and offer a promising strategy for the treatment of neurological disorders such as Alzheimer's disease. The inhibitory effect of 73 native and naturalized plants collected from the central region of Argentina on acetylcholinesterase (AChE) was tested using microplate and TLC assays after solvent fractionation of complete ethanol extracts obtained from the plants. Organic fractions obtained from extracts of Achyrocline tomentosa (Asteraceae), Eupatorium viscidum (Asteraceae), Ruprechtia apetala (Polygonaceae) Trichocline reptans (Asteraceae) and Zanthoxylum coco (Rutaceae) presented strong inhibition of AChE (higher than 80%) at 1 mg/mL, with R. apetala and T. reptans being the most potent, showing complete inhibition of the enzyme. Their IC50 values were 0.0779 and 0.1118 mg/mL, respectively. Aqueous fractions did not show any inhibitory activity on the enzyme. These results suggest that the most effective extracts deserve further investigation with the aim of obtaining new molecules for the treatment of neurodegenerative disorders.
format Artículo
PeerReviewed
author Carpinella, María Cecilia
Andrione, Diego Gabriel
Ruiz, Gustavo Miguel
Palacios, Sara M.
author_facet Carpinella, María Cecilia
Andrione, Diego Gabriel
Ruiz, Gustavo Miguel
Palacios, Sara M.
author_sort Carpinella, María Cecilia
title Screening for acetylcholinesterase inhibitory activity in plant extracts from Argentina
title_short Screening for acetylcholinesterase inhibitory activity in plant extracts from Argentina
title_full Screening for acetylcholinesterase inhibitory activity in plant extracts from Argentina
title_fullStr Screening for acetylcholinesterase inhibitory activity in plant extracts from Argentina
title_full_unstemmed Screening for acetylcholinesterase inhibitory activity in plant extracts from Argentina
title_sort screening for acetylcholinesterase inhibitory activity in plant extracts from argentina
publishDate 2010
url http://pa.bibdigital.ucc.edu.ar/5000/1/A_Carpinella.pdf
work_keys_str_mv AT carpinellamariacecilia screeningforacetylcholinesteraseinhibitoryactivityinplantextractsfromargentina
AT andrionediegogabriel screeningforacetylcholinesteraseinhibitoryactivityinplantextractsfromargentina
AT ruizgustavomiguel screeningforacetylcholinesteraseinhibitoryactivityinplantextractsfromargentina
AT palaciossaram screeningforacetylcholinesteraseinhibitoryactivityinplantextractsfromargentina
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