Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve

Purpose: To determine levels of Peptidyl arginine deiminase 2 (PAD2) and its product protein-bound citrulline in cadaver eyes that suffered from normal tension glaucoma (NTG) compared to primary open angle glaucoma (POAG), and controls. Methods: Western analysis, ELISA, and immunohistochemical analy...

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Autores principales: Cafaro, Thamara A., Santo, Stefanía, Robles, Lucena A., Crim, Nicolás, Urrets Zavalía, Julio, Serra, Horacio M.
Formato: Artículo PeerReviewed
Lenguaje:Español
Publicado: 2010
Materias:
R Medicina (General)
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/4971/1/A_Cafaro.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-4971
record_format dspace
spelling I38-R144-49712025-10-30T15:03:52Z http://pa.bibdigital.ucc.edu.ar/4971/ Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve Cafaro, Thamara A. Santo, Stefanía Robles, Lucena A. Crim, Nicolás Urrets Zavalía, Julio Serra, Horacio M. R Medicina (General) Purpose: To determine levels of Peptidyl arginine deiminase 2 (PAD2) and its product protein-bound citrulline in cadaver eyes that suffered from normal tension glaucoma (NTG) compared to primary open angle glaucoma (POAG), and controls. Methods: Western analysis, ELISA, and immunohistochemical analysis were performed with human tissues. Results: We report over expression of PAD2 and higher levels of its product protein-bound citrulline in the optic nerve of normal tension glaucoma patients (NTG). Conclusions: This is the first report demonstrating that like in POAG, NTG also possesses elevated levels of both PAD2 and protein-bound citrulline. 2010-12-31 Artículo PeerReviewed application/pdf spa http://pa.bibdigital.ucc.edu.ar/4971/1/A_Cafaro.pdf Cafaro, Thamara A., Santo, Stefanía, Robles, Lucena A., Crim, Nicolás, Urrets Zavalía, Julio ORCID: https://orcid.org/0000-0003-2267-2783 <https://orcid.org/0000-0003-2267-2783> and Serra, Horacio M. ORCID: https://orcid.org/0000-0003-4979-8642 <https://orcid.org/0000-0003-4979-8642> (2010) Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve. Molecular Vision, 16. pp. 1654-1658. ISSN 20806090
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic R Medicina (General)
spellingShingle R Medicina (General)
Cafaro, Thamara A.
Santo, Stefanía
Robles, Lucena A.
Crim, Nicolás
Urrets Zavalía, Julio
Serra, Horacio M.
Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve
topic_facet R Medicina (General)
description Purpose: To determine levels of Peptidyl arginine deiminase 2 (PAD2) and its product protein-bound citrulline in cadaver eyes that suffered from normal tension glaucoma (NTG) compared to primary open angle glaucoma (POAG), and controls. Methods: Western analysis, ELISA, and immunohistochemical analysis were performed with human tissues. Results: We report over expression of PAD2 and higher levels of its product protein-bound citrulline in the optic nerve of normal tension glaucoma patients (NTG). Conclusions: This is the first report demonstrating that like in POAG, NTG also possesses elevated levels of both PAD2 and protein-bound citrulline.
format Artículo
PeerReviewed
author Cafaro, Thamara A.
Santo, Stefanía
Robles, Lucena A.
Crim, Nicolás
Urrets Zavalía, Julio
Serra, Horacio M.
author_facet Cafaro, Thamara A.
Santo, Stefanía
Robles, Lucena A.
Crim, Nicolás
Urrets Zavalía, Julio
Serra, Horacio M.
author_sort Cafaro, Thamara A.
title Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve
title_short Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve
title_full Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve
title_fullStr Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve
title_full_unstemmed Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve
title_sort peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve
publishDate 2010
url http://pa.bibdigital.ucc.edu.ar/4971/1/A_Cafaro.pdf
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AT robleslucenaa peptidylargininedeiminasetype2isoverexpressedintheglaucomatousopticnerve
AT crimnicolas peptidylargininedeiminasetype2isoverexpressedintheglaucomatousopticnerve
AT urretszavaliajulio peptidylargininedeiminasetype2isoverexpressedintheglaucomatousopticnerve
AT serrahoraciom peptidylargininedeiminasetype2isoverexpressedintheglaucomatousopticnerve
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