Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve

Purpose: To determine levels of Peptidyl arginine deiminase 2 (PAD2) and its product protein-bound citrulline in cadaver eyes that suffered from normal tension glaucoma (NTG) compared to primary open angle glaucoma (POAG), and controls. Methods: Western analysis, ELISA, and immunohistochemical analy...

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Detalles Bibliográficos
Autores principales: Cafaro, Thamara A., Santo, Stefanía, Robles, Lucena A., Crim, Nicolás, Urrets Zavalía, Julio, Serra, Horacio M.
Formato: Artículo PeerReviewed
Lenguaje:Español
Publicado: 2010
Materias:
R Medicina (General)
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/4971/1/A_Cafaro.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
Descripción
Sumario:Purpose: To determine levels of Peptidyl arginine deiminase 2 (PAD2) and its product protein-bound citrulline in cadaver eyes that suffered from normal tension glaucoma (NTG) compared to primary open angle glaucoma (POAG), and controls. Methods: Western analysis, ELISA, and immunohistochemical analysis were performed with human tissues. Results: We report over expression of PAD2 and higher levels of its product protein-bound citrulline in the optic nerve of normal tension glaucoma patients (NTG). Conclusions: This is the first report demonstrating that like in POAG, NTG also possesses elevated levels of both PAD2 and protein-bound citrulline.

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