Administration of a Peptide Inhibitor of α4-Integrin Inhibits the Development of Experimental Autoimmune Uveitis

Recruitment of lymphocytes into the retina and to the vitreous during the development of experimental autoimmune uveitis (EAU) is governed by factors such as the state of activation of inflammatory cells and the repertoire of adhesion molecules expressed by the local vascular endothelia. alpha4 Inte...

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Detalles Bibliográficos
Autores principales: Martín, Andrea P., Vieira de Moraes, Luciana, Tadokoro, Carlos E., Commodaro, Alessandra G., Urrets Zavalía, Enrique Alberto, Rabinovich, Gabriel A., Urrets Zavalía, Julio, Rizzo, Lucio V., Serra, Horacio M.
Formato: Artículo acceptedVersion
Lenguaje:Español
Publicado: Association for Research in Vision and Ophthalmology 2005
Materias:
RE Oftalmología
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/4272/1/A_Martin_Vieira_R.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
Descripción
Sumario:Recruitment of lymphocytes into the retina and to the vitreous during the development of experimental autoimmune uveitis (EAU) is governed by factors such as the state of activation of inflammatory cells and the repertoire of adhesion molecules expressed by the local vascular endothelia. alpha4 Integrins and their receptors play an important role during homing of cells to the inflammatory site. In the present study, the effect of alpha4-integrin inhibitor on the development of EAU was investigated.

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