Phase II trial with navelbine + cisplatin + etoposide in the treatment of inoperable non-small cell lung carcinoma

40 patients with advanced non-small cell lung cancer not previously treated were included in a study at phase II with vinorelbine 20 mg/Sq.m days 1 and 8, etoposide 60 mg/sq.m days 1-3 and cisplatin 75 mg/sq.m day 1 each 28 days for 6 cycles. There were 31 men and 9 women, being the average age of 5...

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Autores principales: Richardet, Eduardo Arnoldo, Carranza, L., Uribe, A., Tolocka, H., Cresta, Cecilia, Uribe, E., Uribe, M.
Formato: Artículo
Lenguaje:Español
Publicado: 1995
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Acceso en línea:http://pa.bibdigital.ucc.edu.ar/3717/1/A_Richardet_Carranza_Uribe_Tolocka_Cresta_Uribe_Uribe.pdf
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Sumario:40 patients with advanced non-small cell lung cancer not previously treated were included in a study at phase II with vinorelbine 20 mg/Sq.m days 1 and 8, etoposide 60 mg/sq.m days 1-3 and cisplatin 75 mg/sq.m day 1 each 28 days for 6 cycles. There were 31 men and 9 women, being the average age of 54 years, with "performance Status" grade 0-2. All of them could be evaluated for toxicity and 31 for responsiveness. 10 patients were in stage IIIb and 21 at stage IV. 42% of objective responses were obtained and an overall survival of 9 months, which justifies further studies.