Use of Tandem Mass Spectrometry for Multianalyte Screening of Dried Blood Specimens from Newborns

Background:Over the past decade laboratories that test for metabolic disorders have introduced tandem mass spectrometry (MS/MS), which is more sensitive, spe-cific, reliable, and comprehensive than traditional as-says, into their newborn-screening programs. MS/MS is rapidly replacing these one-an...

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Detalles Bibliográficos
Autores principales: Chace, Donald H., Kalas, Theodore A., Naylor, Edwin W.
Formato: Artículo
Lenguaje:Inglés
Publicado: Universidad de Belgrano - Documentos CEEGMD - Centro para el estudio de enfermedades genéticas, metabólicas y discapacidades. Facultad de Ciencias Exactas 2014
Materias:
Tandem Mass Spectrometry
Newborns
Tandem espectrometría de masas
recién nacidos
Multianalyte Screening
Dried Blood Specimens
muestras de sangre seca
Acceso en línea:http://repositorio.ub.edu.ar/handle/123456789/2908
Aporte de:
Repositorio Institucional - Universidad de Belgrano (UB) de Universidad de Belgrano
Descripción
Sumario:Background:Over the past decade laboratories that test for metabolic disorders have introduced tandem mass spectrometry (MS/MS), which is more sensitive, spe-cific, reliable, and comprehensive than traditional as-says, into their newborn-screening programs. MS/MS is rapidly replacing these one-analysis, one-metabolite, one-disease classic screening techniques with a one-analysis, many-metabolites, many-diseases approach that also facilitates the ability to add new disorders to existing newborn-screening panels.

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