Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling
Abstract: Soluble klotho, the shed ectodomain of the antiaging membrane protein α-klotho, is a pleiotropic endocrine/paracrine factor with no known receptors and poorly understood mechanism of action. Soluble klotho down-regulates growth factor-driven PI3K signaling, contributing to extension of lif...
Guardado en:
| Autores principales: | Dalton, George, An, Sung-Wan, Al-Juboori, Saif I., Nischan, Nicole, Yoon, Joonho, Dobrinskikh, Evgenia, Hilgemann, Donald W., Xie, Jian, Luby-Phelps, Kate, Kohler, Jennifer J., Birnbaumer, Lutz, Huang, Chou-Long |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
National Academy of Sciences
2019
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| Materias: | |
| Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/8734 |
| Aporte de: |
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