M1 macrophage polarization is dependent on TRPC1-mediated calcium entry

Abstract: Macrophage plasticity is essential for innate immunity, but in-depth signaling mechanism(s) regulating their functional phenotypes are ill-defined. Here we report that interferon (IFN) γ priming of naive macrophages induces store-mediated Ca2+ entry and inhibition of Ca2+ entry impairs pol...

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Autores principales: Chauhan, Arun, Sun, Yuyang, Sukumaran, Pramod, Quenum Zangbede, Fredice O., Jondle, Christopher N., Sharma, Atul, Evans, Dustin L., Chauhan, Pooja, Szlabick, Randolph E., Aaland, Mary O., Birnbaumer, Lutz, Sharma, Jyotika, Singh, Brij B., Mishra, Bibhuti B.
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier (Cell Press) 2019
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Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8685
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