Central role of G protein Gαi2 and Gαi2+ vomeronasal neurons in balancing territorial and infant-directed aggression of male mice

Abstract: Aggression is controlled by the olfactory system in many animal species. In male mice, territorial and infant-directed aggression are tightly regulated by the vomeronasal organ (VNO), but how diverse subsets of sensory neurons convey pheromonal information to limbic centers is not yet know...

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Autores principales: Trouillet, Anne-Charlotte, Keller, Matthieu, Weiss, Jan, Leinders-Zufall, Trese, Birnbaumer, Lutz, Zufall, Frank, Chamero, Pablo
Formato: Artículo
Lenguaje:Inglés
Publicado: National Academy of Sciences 2019
Materias:
TERRITORIALIDAD
AGRESIVIDAD
PROTEINAS
COMPORTAMIENTO
SISTEMA LIMBICO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8682
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-8682
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic TERRITORIALIDAD
AGRESIVIDAD
PROTEINAS
COMPORTAMIENTO
SISTEMA LIMBICO
spellingShingle TERRITORIALIDAD
AGRESIVIDAD
PROTEINAS
COMPORTAMIENTO
SISTEMA LIMBICO
Trouillet, Anne-Charlotte
Keller, Matthieu
Weiss, Jan
Leinders-Zufall, Trese
Birnbaumer, Lutz
Zufall, Frank
Chamero, Pablo
Central role of G protein Gαi2 and Gαi2+ vomeronasal neurons in balancing territorial and infant-directed aggression of male mice
topic_facet TERRITORIALIDAD
AGRESIVIDAD
PROTEINAS
COMPORTAMIENTO
SISTEMA LIMBICO
description Abstract: Aggression is controlled by the olfactory system in many animal species. In male mice, territorial and infant-directed aggression are tightly regulated by the vomeronasal organ (VNO), but how diverse subsets of sensory neurons convey pheromonal information to limbic centers is not yet known. Here, we employ genetic strategies to show that mouse vomeronasal sensory neurons expressing the G protein subunit Gαi2 regulate male-male and infant-directed aggression through distinct circuit mechanisms. Conditional ablation of Gαi2 enhances male-male aggression and increases neural activity in the medial amygdala (MeA), bed nucleus of the stria terminalis, and lateral septum. By contrast, conditional Gαi2 ablation causes reduced infant-directed aggression and decreased activity in MeA neurons during male-infant interactions. Strikingly, these mice also display enhanced parental behavior and elevated neural activity in the medial preoptic area, whereas sexual behavior remains normal. These results identify Gαi2 as the primary G protein α-subunit mediating the detection of volatile chemosignals in the apical layer of the VNO, and they show that Gαi2+ VSNs and the brain circuits activated by these neurons play a central role in orchestrating and balancing territorial and infant-directed aggression of male mice through bidirectional activation and inhibition of different targets in the limbic system.
format Artículo
author Trouillet, Anne-Charlotte
Keller, Matthieu
Weiss, Jan
Leinders-Zufall, Trese
Birnbaumer, Lutz
Zufall, Frank
Chamero, Pablo
author_facet Trouillet, Anne-Charlotte
Keller, Matthieu
Weiss, Jan
Leinders-Zufall, Trese
Birnbaumer, Lutz
Zufall, Frank
Chamero, Pablo
author_sort Trouillet, Anne-Charlotte
title Central role of G protein Gαi2 and Gαi2+ vomeronasal neurons in balancing territorial and infant-directed aggression of male mice
title_short Central role of G protein Gαi2 and Gαi2+ vomeronasal neurons in balancing territorial and infant-directed aggression of male mice
title_full Central role of G protein Gαi2 and Gαi2+ vomeronasal neurons in balancing territorial and infant-directed aggression of male mice
title_fullStr Central role of G protein Gαi2 and Gαi2+ vomeronasal neurons in balancing territorial and infant-directed aggression of male mice
title_full_unstemmed Central role of G protein Gαi2 and Gαi2+ vomeronasal neurons in balancing territorial and infant-directed aggression of male mice
title_sort central role of g protein gαi2 and gαi2+ vomeronasal neurons in balancing territorial and infant-directed aggression of male mice
publisher National Academy of Sciences
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/8682
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