TRPC6 binds to and activates calpain, independent of its channel activity, and regulates podocyte cytoskeleton, cell adhesion, and motility

Background: Mutations in transient receptor potential channel 6 (TRPC6) are associated with an inherited form of focal segmental glomerulosclerosis (FSGS). Despite widespread expression, patients with TRPC6 mutations do not present with any other pathological phenotype suggesting that this protein h...

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Detalles Bibliográficos
Autores principales: Farmer, Louise K., Rollason, Ruth, Whitcomb, Daniel J., Ni, Lan, Goodliff, Alexander, Lay, Abigail C., Birnbaumer, Lutz, Heesom, Kate J., Xu, Shang-Zhong, Saleem, Moin A., Welsh, Gavin I.
Otros Autores: 0000-0002-2148-6658
Formato: Artículo
Lenguaje:Inglés
Publicado: American Society of Nephrology 2019
Materias:
NEFROLOGIA
MUTACION
GENES
TRASTORNOS GENETICOS
ENFERMEDADES RENALES
RIÑON
PROTEINAS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8678
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina

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