Sleep and the immune system

Abstract: From a physiological perspective the sleep-wake cycle can be envisioned as a sequence of three physiological states, identified by a particular homeostatic patent: wakefulness, non-rapid eye movement (NREM) or slow sleep, and REM sleep. These three physiological states are defined by a par...

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Autores principales: Cardinali, Daniel Pedro, Esquifino, Ana I.
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Bentham Science Publishers 2019
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Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1623
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Sumario:Abstract: From a physiological perspective the sleep-wake cycle can be envisioned as a sequence of three physiological states, identified by a particular homeostatic patent: wakefulness, non-rapid eye movement (NREM) or slow sleep, and REM sleep. These three physiological states are defined by a particular neuroendocrine-immune profile that regulates the immune system response. This review discusses the physiological basis of such a control of the immune system at different sleep stages, as well as the manner in which humoral signals (cytokines) produced by immunocompetent cells modify the mechanisms of sleep.