The chloride anion acts as a second messenger in mammalian cells modifying the expression of specific genes

Abstract: Background/Aims: Cystic Fibrosis (CF) is caused by mutations in the CFTR gene, encoding a cAMP-activated chloride (Cl-) channel. We have previously demonstrated that the expression of several genes can be modulated by the CFTR activity; among them, SRC, MTND4, CISD1, and IL1B. However, the...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Valdivieso, Ángel Gabriel, Clauzure, Mariángeles, Massip Copiz, María Macarena, Santa Coloma, Tomás Antonio
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Karger International 2019
Materias:
GENETICA
BIOLOGIA CELULAR
CLORURO INTRACELULAR
FIBROSIS QUISTICA
BIOMEDICINA
SEGUNDO MENSAJERO
BIOLOGIA MOLECULAR
GENES CFTR DEPENDIENTES
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1454
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
Descripción
Sumario:Abstract: Background/Aims: Cystic Fibrosis (CF) is caused by mutations in the CFTR gene, encoding a cAMP-activated chloride (Cl-) channel. We have previously demonstrated that the expression of several genes can be modulated by the CFTR activity; among them, SRC, MTND4, CISD1, and IL1B. However, the CFTR signalling mechanism involved in the expression of CFTRdependent genes is unknown. The aim of this work was to determine if intracellular chloride (Cl-Clconcentration, regulating in turn the expression of specific genes

Ejemplares similares