High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
Abstract: The therapeutic potential of melatonin as an agent to counteract the consequences of COVID-19 infections is due to its wide-ranging effects as a powerful antioxidant, antiinflammatory, and immunostimulant, as well as to a possible antiviral action. In view of the recently reported eviden...
Guardado en:
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/13678 |
| Aporte de: |
| Sumario: | Abstract: The therapeutic potential of melatonin as an agent to counteract the consequences of
COVID-19 infections is due to its wide-ranging effects as a powerful antioxidant, antiinflammatory, and immunostimulant, as well as to a possible antiviral action. In view of the
recently reported evidence on the occurrence of neurological sequels in COVID-19-infected
patients, another putative application of melatonin emerges based on its neuroprotective
properties. In this manuscript a brief discussion of melatonin activity in animal models of
ischemic and hemorrhagic stroke and the allometric calculations of the possible human
equivalent doses are made. Based on the safety of melatonin, and in order to maximize its
therapeutic opportunity, doses of 100 - 300 mg p.o. or i.v. are proposed. |
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