A randomized study of high-dose pineal hormone melatonin alone versus high-dose melatonin plus low-dose angiotensin-(1-7) in untreatable advanced cancer patients

Abstract: The recent advances in the knowledge of the neuroendocrine control of the immune system and cancer growth have demonstrated the existence of several anticancer natural molecules in the human body, the most promising of them are the pineal hormone melatonin (MLT) and the enzymatic product...

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Autores principales: Lissoni, Paolo, Porro, Giorgio, Monzon, Alejandra, Lissoni, Arianna, Caddeo, Alberto, Messina, Giusy, Di Fede, Giuseppe, Valentini, Agnese, Simoes-e-Silva, Ana Cristina, Cardinali, Daniel Pedro
Formato: Artículo
Lenguaje:Inglés
Publicado: Scientific Research and Community 2022
Materias:
CANCER
MELATONINA
GLANDULA PINEAL
CUIDADOS PALIATIVOS
ANGIOTENSINA 1-7
INMUNIDAD
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/13670
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-13670
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic CANCER
MELATONINA
GLANDULA PINEAL
CUIDADOS PALIATIVOS
ANGIOTENSINA 1-7
INMUNIDAD
spellingShingle CANCER
MELATONINA
GLANDULA PINEAL
CUIDADOS PALIATIVOS
ANGIOTENSINA 1-7
INMUNIDAD
Lissoni, Paolo
Porro, Giorgio
Monzon, Alejandra
Lissoni, Arianna
Caddeo, Alberto
Messina, Giusy
Di Fede, Giuseppe
Valentini, Agnese
Simoes-e-Silva, Ana Cristina
Cardinali, Daniel Pedro
A randomized study of high-dose pineal hormone melatonin alone versus high-dose melatonin plus low-dose angiotensin-(1-7) in untreatable advanced cancer patients
topic_facet CANCER
MELATONINA
GLANDULA PINEAL
CUIDADOS PALIATIVOS
ANGIOTENSINA 1-7
INMUNIDAD
description Abstract: The recent advances in the knowledge of the neuroendocrine control of the immune system and cancer growth have demonstrated the existence of several anticancer natural molecules in the human body, the most promising of them are the pineal hormone melatonin (MLT) and the enzymatic product of ACE2, the angiotensin 1-7 (Ang 1-7). Both MLT and Ang 1-7 have no toxicity, and they exert their antitumor action through several mechanisms, including inhibition of cancer cell proliferation and angiogenesis, and stimulation of the anticancer immunity. Previous preliminary clinical studies had already shown that high-dose MLT may induce a disease control in advanced cancer patients eligible for the only palliative therapy. The present study was performed to evaluate whether the concomitant administration of Ang 1-7 may furtherly increase the antitumor efficacy of MLT in untreatable cancer patients suffering from various tumour histotypes. The study included 70 consecutive advanced untreatable cancer patients, who were randomized to receive the only best supportive care, high-dose MLT (100 mg/day in the dark period), or MLT plus Ang 1-7 (0.5 mg twice/day). The percentage of disease control (DC), including stable disease and tumor regressions, achieved in patients treated by MLT plus Ang 1-7 was significantly higher with respect to those obtained in patients treated with MLT alone (P<0.05) or with the only supportive care (P<0.001). No toxicity was seen under therapy of MLT plus Ang 1-7. In contrast, most patients experienced mood improvement, a diminished anxiety, and a relief of asthenia, which was more evident in patients concomitantly treated by MLT and Ang 1-7.
format Artículo
author Lissoni, Paolo
Porro, Giorgio
Monzon, Alejandra
Lissoni, Arianna
Caddeo, Alberto
Messina, Giusy
Di Fede, Giuseppe
Valentini, Agnese
Simoes-e-Silva, Ana Cristina
Cardinali, Daniel Pedro
author_facet Lissoni, Paolo
Porro, Giorgio
Monzon, Alejandra
Lissoni, Arianna
Caddeo, Alberto
Messina, Giusy
Di Fede, Giuseppe
Valentini, Agnese
Simoes-e-Silva, Ana Cristina
Cardinali, Daniel Pedro
author_sort Lissoni, Paolo
title A randomized study of high-dose pineal hormone melatonin alone versus high-dose melatonin plus low-dose angiotensin-(1-7) in untreatable advanced cancer patients
title_short A randomized study of high-dose pineal hormone melatonin alone versus high-dose melatonin plus low-dose angiotensin-(1-7) in untreatable advanced cancer patients
title_full A randomized study of high-dose pineal hormone melatonin alone versus high-dose melatonin plus low-dose angiotensin-(1-7) in untreatable advanced cancer patients
title_fullStr A randomized study of high-dose pineal hormone melatonin alone versus high-dose melatonin plus low-dose angiotensin-(1-7) in untreatable advanced cancer patients
title_full_unstemmed A randomized study of high-dose pineal hormone melatonin alone versus high-dose melatonin plus low-dose angiotensin-(1-7) in untreatable advanced cancer patients
title_sort randomized study of high-dose pineal hormone melatonin alone versus high-dose melatonin plus low-dose angiotensin-(1-7) in untreatable advanced cancer patients
publisher Scientific Research and Community
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/13670
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