Antiproliferative activity of aqueous and polyphenol-rich extracts of Larrea divaricata Cav. upon a melanoma cell line
Abstract: Most of the deaths from skin cancer are caused by melanoma, a malignancy in which STAT3 plays a crucial role. The inhibition of STAT3 is considered a potential target to induce cell death, tumor regression and metastasis inhibition. The objective of this work was to evaluate the activity...
Guardado en:
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Taylor and Francis
2021
|
| Materias: | |
| Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/12861 |
| Aporte de: |
| Sumario: | Abstract: Most of the deaths from skin cancer are caused by melanoma, a malignancy in which STAT3 plays
a crucial role. The inhibition of STAT3 is considered a potential target to induce cell death, tumor
regression and metastasis inhibition. The objective of this work was to evaluate the activity of the
aqueous extract of Larrea divaricata (Aq), a fraction rich in polyphenols (EA),and the isolated
compound quercetin-3-methyl ether (Q3ME) on B16F10 melanoma cells. The effects of Aq, EA
and Q3ME were assessed on B16F10 cells by determining the proliferation, viability, apoptosis
induction and the expression and phosphorylation of STAT3. The phytochemical composition of
the extracts was determined by High Performance Liquid Chromatography. Aq, EA and Q3ME
presented antiproliferative activity on B6F10 cells through p-STAT3 inhibition and early and late
apoptosis induction (EC50 EA= ≤0.1 μg/ml; Aq= 316±30 μg/ml; Q3ME= <0.1 μg/ml). L. divaricata
could be considered for the development of adjuvant phytotherapies in melanoma treatment. |
|---|