Partial reversal of striatal damage by palmitoylethanolamide administration following perinatal asphyxia

Abstract: Perinatal asphyxia (PA) is a clinical condition brought by a birth temporary oxygen deprivation associated with long-term damage in the corpus striatum, one of the most compromised brain areas. Palmitoylethanolamide (PEA) is a neuromodulator well known for its protective effects in brai...

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Detalles Bibliográficos
Autores principales: Udovin, Lucas Daniel, Kobiec, Tamara, Herrera, María Inés, Toro-Urrego, Nicolás, Kölliker Frers, Rodolfo, Kusnier, Carlos Federico, Ramos Hryb, Ana Belén, Luaces, Juan Pablo, Otero Losada, Matilde, Capani, Francisco
Formato: Artículo
Lenguaje:Inglés
Publicado: Stefano Comai. Universidad de Padua, Italia 2021
Materias:
ASFIXIA PERINATAL
NEURONAS
NEUROPSICOLOGIA
NEURODEGENERACION
NEUROPROTECCION
PALMITOILETANOLAMIDA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/11312
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
Descripción
Sumario:Abstract: Perinatal asphyxia (PA) is a clinical condition brought by a birth temporary oxygen deprivation associated with long-term damage in the corpus striatum, one of the most compromised brain areas. Palmitoylethanolamide (PEA) is a neuromodulator well known for its protective effects in brain injury models, including PA, albeit not deeply studied regarding its particular effects in the corpus striatum following PA. Using Bjelke et al. (1991) PA model, full-term pregnant rats were decapitated, and uterus horns were placed in a water bath at 37 C for 19 min.

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