Boron neutron capture therapy (BNCT) translational studies in the hamster cheek pouch model of oral cancer at the new “B2” configuration of the RA‑6 nuclear reactor
Abstract: Boron neutron capture therapy (BNCT) is based on selective accumulation of B-10 carriers in tumor followed by neutron irradiation. We demonstrated, in 2001, the thera- peutic effect of BNCT mediated by BPA (boronophenyla- lanine) in the hamster cheek pouch model of oral cancer, at the RA-6...
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| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
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Springer Nature
2021
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| Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/11230 |
| Aporte de: |
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I33-R139123456789-11230 |
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| record_format |
dspace |
| institution |
Universidad Católica Argentina |
| institution_str |
I-33 |
| repository_str |
R-139 |
| collection |
Repositorio Institucional de la Universidad Católica Argentina (UCA) |
| language |
Inglés |
| topic |
TERAPIA DE CAPTURA DE NEUTRONES DE BORO (BNCT) CONFIGURACION RA-6 BOLSA DE MEJILLA DE HAMSTER MODELO DE CÁNCER ORAL MUCOSITIS HISTAMINA TEJIDO PRECANCEROSO |
| spellingShingle |
TERAPIA DE CAPTURA DE NEUTRONES DE BORO (BNCT) CONFIGURACION RA-6 BOLSA DE MEJILLA DE HAMSTER MODELO DE CÁNCER ORAL MUCOSITIS HISTAMINA TEJIDO PRECANCEROSO Monti Hughe, Andrea Longhino, Juan Boggio, Esteban Medin, Vanina A. Martinel Lamas, Diego José Garabalin, Marcela A. Heber, Elisa M. Pozzi, Emiliano C. C. Itoiz, María E. Aromando, Romina F. Nigg, David W. Trivillin, Verónica A. Schwint, Amanda E. Boron neutron capture therapy (BNCT) translational studies in the hamster cheek pouch model of oral cancer at the new “B2” configuration of the RA‑6 nuclear reactor |
| topic_facet |
TERAPIA DE CAPTURA DE NEUTRONES DE BORO (BNCT) CONFIGURACION RA-6 BOLSA DE MEJILLA DE HAMSTER MODELO DE CÁNCER ORAL MUCOSITIS HISTAMINA TEJIDO PRECANCEROSO |
| description |
Abstract: Boron neutron capture therapy (BNCT) is based on selective accumulation of B-10 carriers in tumor followed by neutron irradiation. We demonstrated, in 2001, the thera- peutic effect of BNCT mediated by BPA (boronophenyla- lanine) in the hamster cheek pouch model of oral cancer, at the RA-6 nuclear reactor. Between 2007 and 2011, the RA-6 was upgraded, leading to an improvement in the per- formance of the BNCT beam (B2 configuration). Our aim was to evaluate BPA-BNCT radiotoxicity and tumor control in the hamster cheek pouch model of oral cancer at the new “B2” configuration. We also evaluated, for the first time in the oral cancer model, the radioprotective effect of histamine against mucositis in precancerous tissue as the dose-limiting tissue. Cancerized pouches were exposed to: BPA-BNCT; BPA-BNCT + histamine; BO: Beam only; BO + histamine; CONTROL: cancerized, no-treatment. BNCT induced severe mucositis, with an incidence that was slightly higher than in “B1” experiments (86 vs 67%, respectively). BO induced low/moderate mucositis. Histamine slightly reduced the incidence of severe mucositis induced by BPA-BNCT (75 vs 86%) and prevented mucositis altogether in BO animals. Tumor overall response was significantly higher in BNCT (94– 96%) than in control (16%) and BO groups (9–38%), and did not differ significantly from the “B1” results (91%). Histamine did not compromise BNCT therapeutic efficacy. BNCT radiotoxicity and therapeutic effect at the B1 and B2 configurations of RA-6 were consistent. Histamine slightly reduced mucositis in precancerous tissue even in this overly aggressive oral cancer model, without compromising tumor control. |
| format |
Artículo |
| author |
Monti Hughe, Andrea Longhino, Juan Boggio, Esteban Medin, Vanina A. Martinel Lamas, Diego José Garabalin, Marcela A. Heber, Elisa M. Pozzi, Emiliano C. C. Itoiz, María E. Aromando, Romina F. Nigg, David W. Trivillin, Verónica A. Schwint, Amanda E. |
| author_facet |
Monti Hughe, Andrea Longhino, Juan Boggio, Esteban Medin, Vanina A. Martinel Lamas, Diego José Garabalin, Marcela A. Heber, Elisa M. Pozzi, Emiliano C. C. Itoiz, María E. Aromando, Romina F. Nigg, David W. Trivillin, Verónica A. Schwint, Amanda E. |
| author_sort |
Monti Hughe, Andrea |
| title |
Boron neutron capture therapy (BNCT) translational studies in the hamster cheek pouch model of oral cancer at the new “B2” configuration of the RA‑6 nuclear reactor |
| title_short |
Boron neutron capture therapy (BNCT) translational studies in the hamster cheek pouch model of oral cancer at the new “B2” configuration of the RA‑6 nuclear reactor |
| title_full |
Boron neutron capture therapy (BNCT) translational studies in the hamster cheek pouch model of oral cancer at the new “B2” configuration of the RA‑6 nuclear reactor |
| title_fullStr |
Boron neutron capture therapy (BNCT) translational studies in the hamster cheek pouch model of oral cancer at the new “B2” configuration of the RA‑6 nuclear reactor |
| title_full_unstemmed |
Boron neutron capture therapy (BNCT) translational studies in the hamster cheek pouch model of oral cancer at the new “B2” configuration of the RA‑6 nuclear reactor |
| title_sort |
boron neutron capture therapy (bnct) translational studies in the hamster cheek pouch model of oral cancer at the new “b2” configuration of the ra‑6 nuclear reactor |
| publisher |
Springer Nature |
| publishDate |
2021 |
| url |
https://repositorio.uca.edu.ar/handle/123456789/11230 |
| work_keys_str_mv |
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Repositorios |
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