Myocarditis and pericarditis post-mRNA covid-19 vaccination: insights from a pharmacovigilance perspective
Abstract: Concerns remain regarding the rare cardiovascular adverse events, myocarditis and pericarditis (myo/pericarditis), particularly in younger individuals following mRNA COVID-19 vaccination. Our study aimed to comprehensively assess potential safety signals related to these cardiac events fo...
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| Autores principales: | , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/17345 |
| Aporte de: |
| Sumario: | Abstract: Concerns remain regarding the rare cardiovascular adverse events, myocarditis and pericarditis (myo/pericarditis), particularly in younger individuals following mRNA COVID-19 vaccination. Our study aimed to comprehensively assess potential safety signals related to these cardiac
events following the primary and booster doses, with a specific focus on younger populations,
including children as young as 6 months of age. Using the Vaccine Adverse Events Reporting
System (VAERS), the United States national passive surveillance system, we conducted a retrospective pharmacovigilance study analyzing spontaneous reports of myo/pericarditis. We employed
both frequentist and Bayesian methods and conducted subgroup analyses by age, sex, and vaccine
dose. We observed a higher reporting rate of myo/pericarditis following the primary vaccine series,
particularly in males and mainly after the second dose. However, booster doses demonstrated a
lower number of reported cases, with no significant signals detected after the fourth or fifth doses.
In children and young adults, we observed notable age and sex differences in the reporting of
myo/pericarditis cases. Males in the 12–17 and 18–24-year-old age groups had the highest number of
cases, with significant signals for both males and females after the second dose. We also identified
an increased reporting for a spectrum of cardiovascular symptoms such as chest pain and dyspnea,
which increased with age, and were reported more frequently than myo/pericarditis. The present
study identified signals of myo/pericarditis and related cardiovascular symptoms after mRNA
COVID-19 vaccination, especially among children and adolescents. These findings underline the
importance for continued vaccine surveillance and the need for further studies to confirm these
results and to determine their clinical implications in public health decision-making, especially for
younger populations. |
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