Apolipoprotein E4 heterologous expression, purification under non-denaturing conditions, and effects on neuronal clonal cell lines

Abstract: The ε4 allele of the apolipoprotein E gene (APOE4) constitutes the main genetic risk factor for late-onset Alzheimer disease (AD). High amounts of pure apolipoprotein E4 (ApoE4), in a rapid and reproducible fashion, could be of value for studying its pathophysiological roles in AD. The aim...

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Autores principales: Serrano, Ezequiel, Barrantes, Francisco José, Valdivieso, Ángel Gabriel
Formato: Artículo
Lenguaje:Español
Publicado: Elsevier 2023
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Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/16628
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