Compound a, a dissociated glucocorticoid receptor modulator, inhibits t-bet (th1) and induces gata-3 (th2) activity in immune cells

Mostrar todas las versiones(3)

Background: Compound A (CpdA) is a dissociating non-steroidal glucocorticoid receptor (GR) ligand which has anti-inflammatory properties exerted by down-modulating proinflammatory gene expression. By favouring GR monomer formation, CpdA does not enhance glucocorticoid (GC) response element-driven ge...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Liberman, A.C., Antunica-Noguerol, M., Ferraz-de-Paula, V., Palermo-Neto, J., Castro, C.N., Druker, J., Holsboer, F., Perone, M.J., Gerlo, S., de Bosscher, K., Haegeman, G., Arzt, E.
Formato:	Artículo publishedVersion
Publicado:	2012
Materias:	compound A dexamethasone gamma interferon glucocorticoid receptor interleukin 5 mifepristone transcription factor GATA 3 unclassified drug 2 (4 acetoxyphenyl) 2 chloro N methyl ethylammonium chloride 2-(4-acetoxyphenyl)-2-chloro-N-methyl-ethylammonium chloride aziridine derivative Gata3 protein, mouse quaternary ammonium derivative T box transcription factor T box transcription factor TBX21 T-box transcription factor TBX21 animal cell article cell differentiation controlled study cytokine production dimerization enzyme linked immunosorbent assay gene expression immune response immunocompetent cell ligand binding mouse nonhuman protein expression protein phosphorylation reporter gene spleen cell Th1 cell Th2 cell animal Bagg albino mouse biosynthesis drug antagonism drug effect drug potentiation immunology spleen T lymphocyte Th1 Th2 balance Murinae Animals Aziridines GATA3 Transcription Factor Interferon-gamma Mice Mice, Inbred BALB C Mifepristone Quaternary Ammonium Compounds Receptors, Glucocorticoid Spleen T-Box Domain Proteins T-Lymphocytes Th1 Cells Th1-Th2 Balance Th2 Cells
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_19326203_v7_n4_p_Liberman https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_19326203_v7_n4_p_Liberman_oai
Aporte de:	Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

Ejemplares similares

Compound a, a dissociated glucocorticoid receptor modulator, inhibits t-bet (th1) and induces gata-3 (th2) activity in immune cells
por: Liberman, Ana, et al.
Publicado: (2012)

Compound a, a dissociated glucocorticoid receptor modulator, inhibits t-bet (th1) and induces gata-3 (th2) activity in immune cells
por: Liberman, A.C., et al.
Publicado: (2012)

Compound a, a dissociated glucocorticoid receptor modulator, inhibits t-bet (th1) and induces gata-3 (th2) activity in immune cells
por: Liberman, A.C., et al.

Intracellular molecular signaling: Basis for specificity to glucocorticoid anti-inflammatory actions
por: Liberman, Ana, et al.
Publicado: (2009)

Intracellular molecular signaling: Basis for specificity to glucocorticoid anti-inflammatory actions
por: Liberman, A.C., et al.

Cytokine Signaling/Transcription Factor Cross-Talk in T Cell Activation and Th1-Th2 Differentiation
por: Liberman, Ana, et al.
Publicado: (2003)

Cytokine Signaling/Transcription Factor Cross-Talk in T Cell Activation and Th1-Th2 Differentiation
por: Liberman, A.C., et al.

Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production
por: Kovalovsky, Damián, et al.
Publicado: (2000)

Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production
por: Kovalovsky, D., et al.

Integrating systemic information at the molecular level: Cross-talk between steroid receptors and cytokine signaling on different target cells
por: Refojo, Damián, et al.
Publicado: (2003)

Integrating systemic information at the molecular level: Cross-talk between steroid receptors and cytokine signaling on different target cells
por: Refojo, D., et al.

Glucocorticoids inhibit GATA-3 phosphorylation and activity in T cells
por: Liberman, Ana, et al.
Publicado: (2009)

Glucocorticoids inhibit GATA-3 phosphorylation and activity in T cells
por: Liberman, A.C., et al.

Arsenic trioxide alters the differentiation of mouse embryonic stem cell into cardiomyocytes
por: Cebral, Elisa
Publicado: (2015)

Arsenic trioxide alters the differentiation of mouse embryonic stem cell into cardiomyocytes
por: Rebuzzini, P., et al.

The activated glucocorticoid receptor inhibits the transcription factor T-bet by direct protein-protein interaction
por: Liberman, Ana, et al.
Publicado: (2007)

The activated glucocorticoid receptor inhibits the transcription factor T-bet by direct protein-protein interaction
por: Liberman, A.C., et al.

RAC-3 is a NF-κB coactivator
por: Nojek, Ignacio Martín, et al.
Publicado: (2000)

RAC-3 is a NF-κB coactivator
por: Werbajh, S., et al.
Publicado: (2000)

RAC-3 is a NF-κB coactivator
por: Werbajh, S., et al.

RAC-3 is a NF-κB coactivator
por: Werbajh, S., et al.
Publicado: (2000)

GTSE1: A novel TEAD4-E2F1 target gene involved in cell protrusions formation in triple-negative breast cancer cell models
Publicado: (2017)

GTSE1: A novel TEAD4-E2F1 target gene involved in cell protrusions formation in triple-negative breast cancer cell models
por: Stelitano, D., et al.

Mapping the Dynamics of the Glucocorticoid Receptor within the Nuclear Landscape
Publicado: (2017)

Mapping the Dynamics of the Glucocorticoid Receptor within the Nuclear Landscape
por: Stortz, M., et al.

Interferon-γ inhibits cellular proliferation and ACTH production in corticotroph tumor cells through a novel janus kinases-signal transducer and activator of transcription 1/nuclear factor-kappa B inhibitory signaling pathway
Publicado: (2008)

Interferon-γ inhibits cellular proliferation and ACTH production in corticotroph tumor cells through a novel janus kinases-signal transducer and activator of transcription 1/nuclear factor-kappa B inhibitory signaling pathway
por: Labeur, M., et al.

Protein arginine Methyltransferase 8 gene is expressed in pluripotent stem cells and its expression is modulated by the transcription factor Sox2
por: Luzzani, Carlos Daniel, et al.
Publicado: (2016)

Protein arginine Methyltransferase 8 gene is expressed in pluripotent stem cells and its expression is modulated by the transcription factor Sox2
por: Solari, C., et al.

Lack of galectin-3 increases Jagged1/Notch activation in bone marrow-derived dendritic cells and promotes dysregulation of T helper cell polarization
por: Toscano, Marta Alicia
Publicado: (2016)

Lack of galectin-3 increases Jagged1/Notch activation in bone marrow-derived dendritic cells and promotes dysregulation of T helper cell polarization
por: Fermino, M.L., et al.

NF-κB transcriptional activity is modulated by FK506-Binding proteins FKBP51 and FKBP52:A role for peptidyl-prolyl isomerase activity
por: Fontana, Vanina Andrea
Publicado: (2014)

NF-κB transcriptional activity is modulated by FK506-Binding proteins FKBP51 and FKBP52:A role for peptidyl-prolyl isomerase activity
por: Erlejman, A.G., et al.

Dendritic Cells Exposed to Triiodothyronine Deliver Pro-Inflammatory Signals and Amplify IL-17-Driven Immune Responses
Publicado: (2019)

Dendritic Cells Exposed to Triiodothyronine Deliver Pro-Inflammatory Signals and Amplify IL-17-Driven Immune Responses
por: Alamino, V.A., et al.

Molecular understanding of cytokine-steroid hormone dialogue: Implications for human diseases
por: Druker, Jimena Paola, et al.
Publicado: (2006)

Molecular understanding of cytokine-steroid hormone dialogue: Implications for human diseases
por: Druker, J., et al.

Inhibition of Cell Division and DNA Replication Impair Mouse-Naïve Pluripotency Exit
por: Waisman, Ariel, et al.
Publicado: (2017)

Inhibition of Cell Division and DNA Replication Impair Mouse-Naïve Pluripotency Exit
por: Waisman, A., et al.

Interplay between the transcription factors acting on the GATA- and GABA-responsive elements of Saccharomyces cerevisiae UGA promoters
por: Cardillo, Sabrina Beatriz
Publicado: (2012)