Functional Characterization of TLR4 +3725 G/C Polymorphism and Association with Protection against Overweight

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Subclinical low-grade systemic inflammation has been associated with obesity, insulin resistance and metabolic syndrome (MS). Recent studies have highlighted the role of gut microbiota in these disorders. The toll-like receptor 4 (TLR4) plays a key role in the innate immune response activation. We s...

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Detalles Bibliográficos
Autores principales: Penas-Steinhardt, A., Barcos, L.S., Belforte, F.S., de Sereday, M., Vilariño, J., Gonzalez, C.D., Martínez-Larrad, M.T., Tellechea, M.L., Serrano-Ríos, M., Poskus, E., Frechtel, G.D., Leskow, F.C.
Formato: Artículo publishedVersion
Publicado: 2012
Materias:
adiponectin
cysteine
glycine
luciferase
messenger RNA
toll like receptor 4
3' untranslated region
adult
Argentina
article
body mass
cross-sectional study
down regulation
enzyme activity
ethnic group
gene activity
gene expression regulation
gene frequency
gene function
genetic analysis
genetic association
genetic stability
genetic variability
genotype
heterozygote
human
inflammation
lean body weight
major clinical study
male
molecular cloning
obesity
population research
prediction
protection
regulator gene
reporter gene
single nucleotide polymorphism
smoking habit
systemic disease
toll like receptor 4 gene
waist circumference
wild type
3' Untranslated Regions
Adiponectin
Adult
Gene Expression Regulation
Genetic Association Studies
Humans
Immunity, Innate
Insulin Resistance
Male
Metabolic Syndrome X
Obesity
Overweight
Polymorphism, Single Nucleotide
Smoking
Toll-Like Receptor 4
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19326203_v7_n12_p_PenasSteinhardt
https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_19326203_v7_n12_p_PenasSteinhardt_oai
Aporte de:
Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

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