Molecular dynamics of the DNA-binding domain of the papillomavirus E2 transcriptional regulator uncover differential properties for DNA target accommodation

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Papillomaviruses are small DNA tumor viruses that infect mammalian hosts, with consequences from benign to cancerous lesions. The Early protein 2 is the master regulator for the virus life cycle, participating in gene transcription, DNA replication, and viral episome migration. All of these function...

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Autores principales: Falconi, M., Santolamazza, A., Eliseo, T., De Prat-Gay, G., Cicero, D.O., Desideri, A.
Formato: Artículo publishedVersion
Publicado: 2007
Materias:
Molecular dynamics simulation
Papillomavirus
Protein flexibility
Protein-DNA recognition
Transcription factor
early protein 2
transcription factor
unclassified drug
amino acid sequence
article
carboxy terminal sequence
controlled study
DNA binding
gene targeting
Human papillomavirus type 16
molecular dynamics
molecular recognition
nonhuman
nuclear magnetic resonance spectroscopy
Papilloma virus
priority journal
protein DNA binding
protein domain
protein structure
simulation
transcription regulation
virus strain
Animals
Bovine papillomavirus 1
Cattle
DNA, Viral
DNA-Binding Proteins
Human papillomavirus 16
Humans
Oncogene Proteins, Viral
Principal Component Analysis
Protein Binding
Protein Conformation
Protein Structure, Secondary
Viral Proteins
Bovine papillomavirus
Human papillomavirus
Mammalia
Papillomaviridae
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_1742464X_v274_n9_p2385_Falconi
https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_1742464X_v274_n9_p2385_Falconi_oai
Aporte de:
Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

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