Constitutive expression of the α10 nicotinic acetylcholine receptor subunit fails to maintain cholinergic responses in inner hair cells after the onset of hearing

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Efferent inhibition of cochlear hair cells is mediated by α9α10 nicotinic cholinergic receptors (nAChRs) functionally coupled to calcium-activated, small conductance (SK2) potassium channels. Before the onset of hearing, efferent fibers transiently make functional cholinergic synapses with inner hai...

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Detalles Bibliográficos
Autores principales: Taranda, J., Ballestero, J.A., Hiel, H., De Souza, F.S.J., Wedemeyer, C., Gómez-Casati, M.E., Lipovsek, M., Vetter, D.E., Fuchs, P.A., Katz, E., Elgoyhen, A.B.
Formato: Artículo publishedVersion
Publicado: 2009
Materias:
Acetylcholine
Efferent medial olivocochlear
Nicotinic cholinergic receptors
SK2 channel
Transgenic mice
acetylcholine
complementary DNA
messenger RNA
nicotinic acetylcholine receptor alpha10
nicotinic receptor
potassium channel SK2
receptor subunit
small conductance calcium activated potassium channel
unclassified drug
cholinergic receptor stimulating agent
Chrna10 protein, mouse
homeodomain protein
Kcnn2 protein, mouse
Pou4f3 protein, mouse
transcription factor POU4F3
animal experiment
animal tissue
article
cholinergic synapse
Chrna10 gene
controlled study
down regulation
efferent nerve
evoked response
gene expression
genetic transcription
hair cell
hearing
in situ hybridization
mouse
nonhuman
patch clamp
potassium current
Pou4f3 gene
priority journal
promoter region
receptor gene
RNA translation
transgene
transgenic mouse
wild type
animal
animal model
cytology
drug effect
genetics
metabolism
physiology
Animals
Cholinergic Agents
Hair Cells, Auditory, Inner
Hearing
Homeodomain Proteins
Mice
Mice, Transgenic
Models, Animal
Patch-Clamp Techniques
Receptors, Nicotinic
RNA, Messenger
Small-Conductance Calcium-Activated Potassium Channels
Transcription Factor Brn-3C
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_15253961_v10_n3_p397_Taranda
https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_15253961_v10_n3_p397_Taranda_oai
Aporte de:
Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

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