Reversion of lethality and growth defects in Fatiga oxygen-sensor mutant flies by loss of Hypoxia-Inducible Factor-α/Sima

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Hypoxia-Inducible Factor (HIF) prolyl hydroxylase domains (PHDs) have been proposed to act as sensors that have an important role in oxygen homeostasis. In the presence of oxygen, they hydroxylate two specific prolyl residues in HIF-α polypeptides, thereby promoting their proteasomal degradation. So...

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Detalles Bibliográficos
Autores principales: Centanin, L., Ratcliffe, P.J., Wappner, P.
Formato: Artículo publishedVersion
Publicado: 2005
Materias:
Drosophila
Hypoxia-inducible factor
Oxygen sensor
Sima
Drosophila protein
hypoxia inducible factor alpha
mutant protein
oxygen
protein Fatiga
unclassified drug
article
cell size
controlled study
developmental disorder
developmental stage
gene mutation
genetic code
growth disorder
lethality
mutant
nonhuman
null allele
oxygen sensing
priority journal
protein depletion
protein function
regulatory mechanism
survival
Animals
Cell Hypoxia
Cell Size
DNA-Binding Proteins
Drosophila melanogaster
Drosophila Proteins
Gene Expression Regulation, Developmental
Genes, Lethal
Hypoxia-Inducible Factor 1, alpha Subunit
Larva
Oxygen
Phenotype
Procollagen-Proline Dioxygenase
RNA, Messenger
Time Factors
Metazoa
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_1469221X_v6_n11_p1070_Centanin
https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_1469221X_v6_n11_p1070_Centanin_oai
Aporte de:
Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

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