Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells

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Interactions between steroid hormone receptors and signal transducer and activator of transcription (Stat)-mediated signaling pathways have already been described. In the present study, we explored the capacity of progestins to modulate Stat3 transcriptional activation in an experimental model of ho...

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Autores principales:	Proietti, C., Salatino, M., Rosemblit, C., Carnevale, R., Pecci, A., Kornblihtt, A.R., Molinolo, A.A., Frahm, I., Charreau, E.H., Schillaci, R., Elizalde, P.V.
Formato:	Artículo publishedVersion
Publicado:	2005
Materias:	4 amino 7 tert butyl 5 (4 chlorophenyl)pyrazolo[3,4 d]pyrimidine antigestagen Janus kinase Janus kinase 1 Janus kinase 2 medroxyprogesterone acetate mifepristone mutant protein progesterone derivative protein tyrosine kinase STAT3 protein steroid receptor animal cell animal experiment animal model animal tissue article breast adenocarcinoma breast cancer cancer cell cancer model cell growth cell proliferation controlled study enzyme activity enzyme inhibition expression vector female gene induction genetic transfection hormonal carcinogenesis hormonal regulation mouse nonhuman oncogene src priority journal protein DNA binding protein expression protein phosphorylation protein protein interaction protein targeting signal transduction transcription initiation tumor growth Active Transport, Cell Nucleus Animals Antineoplastic Agents, Hormonal Breast Neoplasms Cell Line, Tumor DNA DNA-Binding Proteins Epithelial Cells Female Humans Janus Kinase 1 Janus Kinase 2 Medroxyprogesterone 17-Acetate Mice Mice, Inbred BALB C Progestins Protein-Tyrosine Kinases Proto-Oncogene Proteins Receptors, Progesterone src-Family Kinases STAT3 Transcription Factor Trans-Activation (Genetics) Trans-Activators
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_02707306_v25_n12_p4826_Proietti https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_02707306_v25_n12_p4826_Proietti_oai
Aporte de:	Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

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