Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice

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Type 1 diabetes (T1D) is a disease caused by the destruction of the β cells of the pancreas by activated T cells. Dendritic cells (BC) are the APC that initiate the T cell response that triggers T1D. However, DC also participate in T cell tolerance, and genetic engineering of DC to modulate T cell i...

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Autores principales: Perone, M.J., Bertera, S., Tawadrous, Z.S., Shufesky, W.J., Piganelli, J.D., Baum, L.G., Trucco, M., Morelli, A.E.
Formato: Artículo publishedVersion
Publicado: 2006
Materias:
galectin 1
gamma interferon
adoptive transfer
animal cell
animal experiment
animal model
animal tissue
antigen presenting cell
apoptosis
article
autoimmune disease
CD4+ T lymphocyte
cellular immunity
controlled study
cytokine release
dendritic cell
disease model
down regulation
female
GAL1 gene
genetic engineering
insulin dependent diabetes mellitus
insulitis
lymph node
lymphocyte proliferation
mouse
nonhuman
pancreas islet beta cell
priority journal
protein function
protein synthesis
spleen
T lymphocyte activation
Th1 cell
transgene
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00221767_v177_n8_p5278_Perone
https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00221767_v177_n8_p5278_Perone_oai
Aporte de:
Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

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