Impairment of mineralocorticoid receptor (MR)-dependent biological response by oxidative stress and aging: Correlation with post-translational modification of MR and decreased ADP-ribosylatable level of elongation factor 2 in kidney cells

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Acute and chronic treatments of mice with the glutathione-depleting agent, L-buthionine-(SR)-sulfoximine (BSO), impaired the mineralocorticoid receptor (MR)-dependent biological response by inhibiting aldosterone binding. This steroid-binding inhibition was fully reversed when reducing agents were a...

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Detalles Bibliográficos
Autores principales: Piwien-Pilipuk, G., Ayala, A., Machado, A., Galigniana, M.D.
Formato: Artículo publishedVersion
Publicado: 2002
Materias:
Biological organs
Carbonylation
Cells
Monomers
Oligomers
Proteins
Oxidative stress
Biochemistry
buthionine sulfoximine
elongation factor 2
mineralocorticoid receptor
adenosine diphosphate ribosylation
aging
animal cell
animal model
article
controlled study
correlation analysis
cytosol
hormone binding
inhibition kinetics
male
mouse
nonhuman
oxidative stress
priority journal
protein degradation
protein depletion
protein expression
protein modification
protein processing
protein structure
structure analysis
translation initiation
ADP-Ribosylation Factors
Aging
Animals
Antimetabolites
Buthionine Sulfoximine
Cytosol
Enzyme Inhibitors
Glutathione
HSP90 Heat-Shock Proteins
Kidney
Male
Mice
Mice, Inbred BALB C
Oxidation-Reduction
Oxidative Stress
Oxygen
Peptide Elongation Factor 2
Polyribosomes
Precipitin Tests
Protein Binding
Protein Biosynthesis
Protein Processing, Post-Translational
Receptors, Mineralocorticoid
Reticulocytes
Time Factors
Transcription, Genetic
Animalia
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00219258_v277_n14_p11896_PiwienPilipuk
https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00219258_v277_n14_p11896_PiwienPilipuk_oai
Aporte de:
Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

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