Influence of the strain of rats on the induction of hexachlorobenzene induced porphyria

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1. 1. The present work undertakes a comparative study on the hexachlorobenzene (HCB) porphyria induction in female rats of Wistar and CHBBTHOM strains. The purpose was to characterize the CHBBTHOM strain with respect to the haem metabolic pathway, its regulatory mechanisms and its response to foreig...

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Detalles Bibliográficos
Autores principales: Wainstok de Calmanovici, R., Billi de Catabbi, S.C., Aldonatti, C.A., San Martin de Viale, L.C.
Formato: Artículo publishedVersion
Publicado: 1989
Materias:
5 aminolevulinate synthase
aminolevulinic acid
heme
hexachlorobenzene
porphobilinogen
porphyrin
uroporphyrinogen decarboxylase
xenobiotic agent
animal cell
animal experiment
animal model
female
hepatic porphyria
iron liver level
nonhuman
oral drug administration
rat
regulatory mechanism
strain difference
urinary excretion
5-Aminolevulinate Synthetase
Animal
Carboxy-Lyases
Chlorobenzenes
Comparative Study
Female
Hexachlorobenzene
Iron
Liver
Liver Diseases
Porphyria
Porphyrins
Rats
Rats, Inbred Strains
Species Specificity
Support, Non-U.S. Gov't
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0020711X_v21_n4_p377_WainstokdeCalmanovici
http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_0020711X_v21_n4_p377_WainstokdeCalmanovici_oai
Aporte de:
Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires
Descripción
Sumario:1. 1. The present work undertakes a comparative study on the hexachlorobenzene (HCB) porphyria induction in female rats of Wistar and CHBBTHOM strains. The purpose was to characterize the CHBBTHOM strain with respect to the haem metabolic pathway, its regulatory mechanisms and its response to foreign drugs. 2. 2. After 7 weeks of treatment it was observed that the hepatic porphyrins increased 140 times, ALA-synthase 4 times and PCL was 73% inhibited in the Wistar strain. 3. 3. On the other hand the animals of CHBBTHOM strain showed lesser alteration on these parameters; hepatic porphyrins increased only 3-fold, ALA-synthase 1.7-fold and PCL was only 22% inhibited. 4. 4. Total iron liver content was nearly equal in both strains of rats. 5. 5. The results obtained would indicate that the lower susceptibility of the CHBBTHOM strain to acquire porphyria does not seem to be due to either: (1) congenital alterations of any parameters of the haem metabolic pathway, since the behaviour of normal animals from both strains was similar; or (2) a lower hepatic iron content in such animals. 6. 6. These findings would suggest that the differential response to HCB to this strain would be looked for in another metabolic pathway, such as that involved in the metabolization process of the toxic. © 1989.

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