Spermidine is essential for normal proliferation of trypanosomatid protozoa

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Trypanosomatid parasites containing a metabolically unstable ornithine decarboxylase (ODC) are naturally resistant to high levels of α-difluoromethylornithine (DFMO) because this ODC inhibitor, though causing a drastic reduction of intracellular putrescine, elicits only a moderate decrease of the sp...

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Detalles Bibliográficos
Autores principales: González, N.S., Huber, A., Algranati, I.D.
Formato: Artículo publishedVersion
Publicado: 2001
Materias:
Cyclohexylamine
Polyamine
Spermidine
Spermidine synthase
Trypanosomatid proliferation
eflornithine
eticyclidine
ornithine decarboxylase
putrescine
spermidine
article
cell proliferation
controlled study
Crithidia fasciculata
enzyme stability
nonhuman
priority journal
protozoon
Trypanosoma cruzi
Animals
Cyclohexylamines
Eflornithine
Enzyme Inhibitors
Ornithine Decarboxylase
Putrescine
Spermidine Synthase
Spermine
Protozoa
Trypanosomatidae
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00145793_v508_n3_p323_Gonzalez
http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00145793_v508_n3_p323_Gonzalez_oai
Aporte de:
Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

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