Identification of cleavage regulatory mechanisms and phenotypic consequences to targeting of the ADAM 17/ EGFR axis in triple negative breast cancer (TNBC) in-vitro
Ectodomain cleavage of cel l-surface proteins by A Disintegrin And\nMetalloproteinases (ADAMs) is highly regulated, and its dysregulation has\nbeen l inked to many diseases. ADAM17-dependent Epidermal Growth Factor\n(EGF) pro-ligand cleavage drives mammary carcinogenesis, proliferation,\nmigration a...
Guardado en:
Autor principal: | Bagchi, Udita |
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Otros Autores: | Borner, Chistoph |
Formato: | Tesis de maestría acceptedVersion |
Lenguaje: | Inglés |
Publicado: |
Facultad de Farmacia y Bioquímica
2015
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Materias: | |
Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=afamaster&cl=CL1&d=HWA_832 http://repositoriouba.sisbi.uba.ar/gsdl/collect/afamaster/index/assoc/HWA_832.dir/832.PDF |
Aporte de: |
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