Acción de flavanoles sobre la función vascular : óxido nítrico y mecanismos antioxidantes
Antihypertensive and antioxidant mechanisms of the flavanol(?)-epicatechin, found in abundance in the human diet, were studied. In vitro it was shown that the ability of (?)-epicatechin to trap alcoxyl radical and superoxide anion (direct antioxidant action) is high, but irrelevantcompared to otherc...
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| Formato: | Tesis doctoral acceptedVersion |
| Lenguaje: | Español |
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Facultad de Farmacia y Bioquímica
2015
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_813 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_813.dir/813.PDF |
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| Sumario: | Antihypertensive and antioxidant mechanisms of the flavanol(?)-epicatechin, found in abundance in the human diet, were studied. In vitro it was shown that the ability of (?)-epicatechin to trap alcoxyl radical and superoxide anion (direct antioxidant action) is high, but irrelevantcompared to othercompounds at the usual tissue concentrations. (?)-Epicatechin exerted a vasodilating effect in isolated aorta, but this effect was not significant at the concentration reaches by this compound in blood. In vivo, in experimental models of increased blood pressure in rats by administration of L -NAME or fructose overload (?)-epicatechinprevented the increase in blood pressure produced by the treatments through restoring nitric oxide (NO) bioavailability to control values in association with: i) increased NO synthase activity, unmodified eNOS expression (and higher phosphorylation at Ser1177 phosphorylation and restoration of low caveolin-1 in fructose model), and ii) prevention of oxidative stress mediated by NADPH-oxidase, modulating the expression of p47phox (and p22phoxin fructose model). It is concluded\nthat the antihypertensive action of (?)-epicatechindoes not involve, at least solely, direct antioxidant mechanisms but a set of indirect antioxidant mechanisms. |
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