Caracterización molecular de las cepas de Chlamydia trachomatis presentes en el brote de limfogranuloma venéreo en la ciudad de Buenos Aires, período 2017-2019
Lymphogranuloma venereum (LGV) is a sexually transmitted systemic infection caused by Chlamydia trachomatis genotypes L. A 2003 outbreak in the Netherlands primarily affected HIV-positive men who have sex with men, featuring L2b genotypes. In 2017 a similar outbreak was identified in Buenos Aires. T...
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| Formato: | Tesis doctoral acceptedVersion |
| Lenguaje: | Español |
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Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica
2024
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_7865 https://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_7865.dir/7865.PDF |
| Aporte de: |
| Sumario: | Lymphogranuloma venereum (LGV) is a sexually transmitted systemic infection caused by Chlamydia trachomatis genotypes L. A 2003 outbreak in the Netherlands primarily affected HIV-positive men who have sex with men, featuring L2b genotypes. In 2017 a similar outbreak was identified in Buenos Aires. This thesis molecularly characterized L genotypes in Buenos Aires from 2017 to 2019. The prevalence of C. trachomatis in proctitis was 45.30%. Being 83.02% of those caused by L genotypes, these included L2, L2b with variants L2bv1, L2bv5, and new L2bv12, L2bv13, and L2bv14, as well as a new L2i variant, and a L1-like genotype having ten mutations compared to L1/440. LGV patients had more severe symptoms and a significant association with HIV and oro-anal sexual practices compared to non-LGV cases. MLST identified L2/L2b genotypes as ST58, ST141, ST143, and the new ST60, while L1-like samples were the first to be in ST2. Phylogenetic analysis revealed two clades: one for L2b, including L2, L2i, and L2b variants, and a new clade for L1-like strains, proposed as genotype ompA L4. This study highlights the local genetic diversity within the LGV outbreak, its difference with the European outbreak, and the need for further research. |
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