Impacto de los receptores GABAb sobre el sistema kisspeptidérgico en ratones machos y hembras: implicancias en el eje endocrino/reproductivo
In this Doctoral Thesis we show that blocking the GABAB receptor (GABABR) signaling at critical periods of postnatal development causes permanent alterations in essential factors for the proper development and functioning of the gonadotrophic axis.\nWe describe that a GABAergic input, through the, G...
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| Formato: | Tesis doctoral acceptedVersion |
| Lenguaje: | Español |
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Facultad de Farmacia y Bioquímica
2020
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_6296 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_6296.dir/6296.PDF |
| Aporte de: |
| Sumario: | In this Doctoral Thesis we show that blocking the GABAB receptor (GABABR) signaling at critical periods of postnatal development causes permanent alterations in essential factors for the proper development and functioning of the gonadotrophic axis.\nWe describe that a GABAergic input, through the, GABABR during the early postnatal window is necessary for the correct expression of genes that are critical for reproductive function, such as Kiss1, Tac2 and Gnrh1; and genes that code for neurotransmitter synthesis enzymes such as Gad1 and Th. Changes in the normal patterns of expression of these genes due to alterations in GABA signaling cause downstream effects on the reproductive axis, impacting not only neonatal development, but later stages like adulthood.\nWe also demonstrate that GABA through its GABAB receptors can modulate the expression of key genes for reproduction beyond the perinatal window.\nBy prolonging the treatment to the PND21, we observe alterations that compromise, in various ways, the developing and adult reproductive axis. In this case the expression of Kiss1 is also affected in the antero ventro-periventricular nucleus in females. |
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