Desarrollo de nanopartículas de sílice con potencial uso terapéutico: estudio de sus efectos sobre el tejido sanguíneo y células del sistema inmune
In recent years, nanotechnology has been of growing interest in the fields of medicine and\nphysiology because its application could greatly improve the detection and treatment of\ndiseases and, although the potential is considerable, there are still many challenges that\nmust be addressed before th...
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| Formato: | Tesis doctoral acceptedVersion |
| Lenguaje: | Español |
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Facultad de Farmacia y Bioquímica
2018
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_5789 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_5789.dir/5789.PDF |
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| Sumario: | In recent years, nanotechnology has been of growing interest in the fields of medicine and\nphysiology because its application could greatly improve the detection and treatment of\ndiseases and, although the potential is considerable, there are still many challenges that\nmust be addressed before the use of them is routinely accepted at the clinical level. In this\nsense, in this work, nanoparticles were synthesized, characterized and evaluated with the\naim of applying them in the diagnosis and treatment of cancer. It was observed that the\nNPs when entering the bloodstream could interact with the components of the blood and\nin particular of the immune system, affecting the functions of the coagulation cascade, the\nplatelets, the red blood cells and activating the macrophages. In addition, synthesis\nprotocols were developed to obtain nanoparticles suitable for the encapsulation of drugs\nand the union of diagnostic agents. It was also observed that they can be degraded in\nphysiological and pathological environments, being able to release the load they transport.\nLikewise, it was demonstrated that nanoparticles with monoclonal antibodies adsorbed on\ntheir surface were able to activate antitumor profiles in macrophages and neutrophils and\nat the same time act on tumor cells, decreasing the size of the tumors. |
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